Therapeutic Drug Monitoring (TDM) Pricing and Sample Collection Protocols

Effective October 1, 2023

TDM Pricing Information (PDF)

Anti-epileptics

Most tests (except cyclosporine) require 0.5 mL serum or plasma.
Transfer separated serum or plasma to a plastic transport tube.
Do not use a gel barrier tube. The use of gel-barrier tubes is not recommended due to the slow absorption of the drug by the gel. Depending on the specimen volume and storage times, the decrease in drug level due to absorption may affect a test result and interpretation.
Please do not freeze samples.

BND = Before the next dose

Drugs	Sample required (No separator gel)	Collection time (Post-dose)		Day Run	Price		Method	Ship on ice	Notes
Drugs	Sample required (No separator gel)	Peak	Trough		Single	Peak & Trough
Bromide	0.5 mL Serum /Plasma	BND		T, R	$55		Gold chloride	No	Do not use a gel barrier tube.
Gabapentin	0.5 mL Serum /Plasma	2 hrs	BND Preferred sample if only one is submitted.	As received	$80	$115	Immunoassay	No	Do not use a gel barrier tube.
Levetiracetam (Keppra®)	0.5 mL Serum (NO plasma)	2 hrs	BND Preferred sample if only one is submitted.	T, W, R, F	$80	$115	Immunoassay	No	Do not use a gel barrier tube. Please draw in a red top tube, allow time to clot, spin down, draw off, and send the serum. Only serum provides the cleanest sample and, therefore, the most accurate results.
Phenobarbital	0.5 mL Serum /Plasma	2 hrs	BND Preferred sample if only one is submitted.	T, W, R, F	$35	$50	Immunoassay	No	Do not use a gel barrier tube. Fasting sample recommended
Phenytoin (Dilantin®)	0.5 mL Serum /Plasma	BND	Preferred sample if only one is submitted.	As received	$55	$80	Immunoassay	Yes	Do not use a gel barrier tube. Fasting sample recommended
Valproic acid	0.5 mL Serum /Plasma	2 hrs	BND Preferred sample if only one is submitted.	As received	$55	$80	Immunoassay	Yes	Do not use a gel barrier tube.
Zonisamide	0.5 mL Serum /Plasma	2 hrs	BND Preferred sample if only one is submitted.	T, R	$80	$115	Immunoassay	No	Do not use a gel barrier tube. Serum or plasma should be separated from red blood cells as soon as possible. Excessive hemolysis may interfere with the assay.

Immunomodulators

Most tests (except cyclosporine) require 0.5 mL serum or plasma.
Transfer separated serum or plasma to a plastic transport tube.
Do not use a gel barrier tube. The use of gel-barrier tubes is not recommended due to the slow absorption of the drug by the gel. Depending on the specimen volume and storage times, the decrease in drug level due to absorption may affect a test result and interpretation.
Please do not freeze samples.

BND = Before the next dose

Drugs	Sample required (No separator gel)	Collection time (Post-dose)		Day Run	Price		Method	Ship on ice	Notes
Drugs	Sample required (No separator gel)	Peak	Trough		Single	Peak & Trough
Cyclosporine	0.5 mL EDTA whole blood (purple top)	1.5–2 hrs Preferred sample if only one is submitted.	BND	W, F	$65	$105	Immunoassay	No	Do not use a gel barrier tube. Recommend peak & trough the first time to establish a half-life. A level may be too low to detect if a sample is drawn >12 hours post‐dose.
Leflunomide	0.5 mL Serum /Plasma		BND	Every other Monday	$100	$115	HPLC	No	Do not use a gel barrier tube.
Mycophenolate (Mycophenolic acid)	0.5 mL Plasma	1–2 hrs	BND	W, F	$75	$120	Immunoassay	Yes	Do not use a gel barrier tube. Recommend peak & trough the first time to establish a half-life. A level may be too low to detect if a sample is drawn >12 hours post‐dose.

Antimicrobials

Most tests (except cyclosporine) require 0.5 mL serum or plasma.
Transfer separated serum or plasma to a plastic transport tube.
Do not use a gel barrier tube. The use of gel-barrier tubes is not recommended due to the slow absorption of the drug by the gel. Depending on the specimen volume and storage times, the decrease in drug level due to absorption may affect a test result and interpretation.
Please do not freeze samples.

BND = Before the next dose

Drugs	Sample required (No separator gel)	Collection time (Post-dose)		Day Run	Price		Method	Ship on ice	Notes
Drugs	Sample required (No separator gel)	Peak	Trough		Single	Peak & Trough
Amikacin	0.5 mL Serum /Plasma	1 hr	BND (for toxicity) 4-6 hrs (for half-life)	As received	$105	$130	Immunoassay	Yes	Do not use a gel barrier tube. No glass tube
Gentamicin	0.5 mL Serum /Plasma	2 hrs	BND	As received	$50	$75	Immunoassay	Yes	Do not use a gel barrier tube.
Vancomycin	0.5 mL Serum /Plasma	2 hrs	BND	As received	$50	$75	Immunoassay	Yes	Do not use a gel barrier tube. Fasting sample recommended

Antifungals

Most tests (except cyclosporine) require 0.5 mL serum or plasma.
Transfer separated serum or plasma to a plastic transport tube.
Do not use a gel barrier tube. The use of gel-barrier tubes is not recommended due to the slow absorption of the drug by the gel. Depending on the specimen volume and storage times, the decrease in drug level due to absorption may affect a test result and interpretation.
Please do not freeze samples.

BND = Before the next dose

Drugs	Sample required (No separator gel)	Collection time (Post-dose)		Day Run	Price		Method	Ship on ice	Notes
Drugs	Sample required (No separator gel)	Peak	Trough		Single	Peak & Trough
Itraconazole	0.5 mL Serum /Plasma	3-4 hrs	BND	As received	$120	$150	HPLC	No	Do not use a gel barrier tube.
Voriconazole	0.5 mL Serum /Plasma	3-4 hrs	BND	As received	$100	$120	HPLC	No	Do not use a gel barrier tube.

Others

Most tests (except cyclosporine) require 0.5 mL serum or plasma.
Transfer separated serum or plasma to a plastic transport tube.
Do not use a gel barrier tube. The use of gel-barrier tubes is not recommended due to the slow absorption of the drug by the gel. Depending on the specimen volume and storage times, the decrease in drug level due to absorption may affect a test result and interpretation.
Please do not freeze samples.

BND = Before the next dose

Drugs	Sample required (No separator gel)	Collection time (Post-dose)		Day Run	Price		Method	Ship on ice	Notes
Drugs	Sample required (No separator gel)	Peak	Trough		Single	Peak & Trough
Digoxin	0.5 mL Serum /Plasma	1.5-2 hrs	BND	As received	$55	$85	Immunoassay	Yes	Do not use a gel barrier tube.
Lidocaine	0.5 mL Serum /Plasma	2-4 hrs	BND	As received	$55	$85	Immunoassay	Yes	Do not use a gel barrier tube.
Procainamide	0.5 mL Serum /Plasma			As received	$55	$85	Immunoassay	Yes	Do not use a gel barrier tube.
Theophylline	0.5 mL Serum /Plasma	2 hrs		As received	$55	$85	Immunoassay	Yes	Do not use a gel barrier tube.

STAT Fee

Non-HPLC	$60 (first test) and $30 (subsequent tests)
HPLC	$200

Handling Fee

Non-human primate samples	$50 per test
Processing fee for paper submission	$5 per test