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Specific insulin formulations must be administered with the appropriate insulin syringe which matches the concentration of insulin used. The concentration of any particular formulation is marked on the vial as U-100 (100 units per milliliter), U-40 (40 units per milliliter), etc. All U-100 insulins must be administered using U-100 syringes and all U-40 formulations of insulin must be administered using U-40 syringes, or severe dosage errors may result. The size of the needles vary from 26 gauge to 29 gauge in diameter. The volume of insulin accommodated also varies between syringes, from ? cc (1 cc is the same as 1 milliliter or ml) capacity (25 units of a U-100 insulin), ? cc capacity (30 units of a U-100 insulin), ? cc capacity (50 units of a U-100 insulin) to 1cc (100 units of a U-100 insulin). U-40 syringes all accommodate 1 cc of U-40 insulin.
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