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Frank F. Bartol, MS, PhD


Dr. Frank F. (Skip) Bartol, Professor in the Department of Anatomy, Physiology and Pharmacology, joined the Auburn University faculty in 1983.  A native of Virginia, Bartol received the B.S. degree from Virginia Tech, both M.S. and Ph.D. degrees from the University of Florida through the Interdisciplinary Reproductive Biology (UF-IRB) program, and advanced training in molecular biology as a visiting scientist in the Center for Animal Biotechnology at Texas A&M University (TAMU).  Bartol served as Director of the AU Cellular and Molecular Biosciences Program from 2001 until his appointment as Associate Dean for Research and Graduate Studies in the AU College of Veterinary Medicine in July, 2009. 

Research Interest

His research focuses on identification of factors affecting and mechanisms regulating development and function of the female reproductive tract, with a particular focus on reproductive efficiency and health in domestic ungulate species.  Notable interdisciplinary advances realized through his research include development of the "uterine gland knockout" (UGKO) model, with colleagues at TAMU, and promulgation of the "lactocrine hypothesis" for maternal programming of neonatal somatic tissues, developed with colleagues at Rutgers University.  In 2005, Dr. Bartol was named "Donald Henry Barron Lecturer" by the UF-IRB program at his doctoral alma mater "for outstanding research and scholarly activities in the field of reproductive biology".  He was named "Alumni Professor" at Auburn University in 2009.

Selected Publications

Camp ME, Wiley AA, Boulos MB, Rahman KM, Bartol F, Bagnell C. Effects of age, nursing, and oral IGF1 supplementation on neonatal porcine cervical development.  Reproduction. 2014. PMID:  25074922;

Rahman KM, Lovich JE, Lam C, Camp ME, Wiley AA, Bartol FF, Bagnell CA.  Nursing supports neonatal porcine testicular development.  Dom Anim Endocrinol. 48:84-92, 2014.

Nanjappa MK, Ahuja M, Dhanasekaran M, Coleman ES, Braden TD, Bartol FF, Wanders D, Judd RL, Akingbemi BT.  Bisphenol A regulation of testicular endocrine function in male rats is affected by diet.  Toxicol Lett.  2014. 225:479-487.

Cooke PS, Spencer TE, Bartol FF, Hayashi K.  Uterine glands: development, function and experimental model systems.  Molecular Human Reproduction / New Research Horizon Review.  2013. doi:10.1093/molehr/gat031

Miller DJ, Wiley AA, Chen JC, Bagnell CA, Bartol FF.  Nursing for 48 hours from birth supports porcine uterine gland development and endometrial cell compartment-specific gene expression.  2012.  Biology of Reproduction.  DOI: 10.1095/biolreprod.112.105056

Bartol FF, Wiley AA, Miller DJ, Silva AJ, Roberts KE, Davolt MLP, Chen JC, Frankshun A-L, Camp ME, Rahman KM, Vallet JL, Bagnell CA.  Lactocrine signaling and developmental programming (Invited Review; Special Topics, Contemporary Issues).  2012.  Journal of Animal Science. doi: 10.2527/jas.2012-5764

Cooke PS, Borsdorf DC, Ekman GC, Doty KF, Clark SG, Dziuk PJ, Bartol FF.  Uterine gland development begins postnatally and is accompanied by estrogen and progesterone receptor expression in the dog.  Theriogenology. 2012. doi: 10.1016/j.theriogenology.2012.05.028

Frankshun AL, Chen JC, Barron LA, Ho TY, Miller DJ, Rahman KM, Bartol FF, Bagnell CA. Nursing during the first two days of life is essential for the expression of proteins important for growth and remodeling of the neonatal porcine cervix. Endocrinology. 2012. 153. doi: 10.1210/en.2012-1329.

Cooke PS, Ekman GC, Kaur J, Davila J, Bagchi IC, Clark SG, Dziuk PJ, Hayashi I, Bartol FF. Brief exposure to progesterone during a critical neonatal window prevents uterine gland formation in mice. Biology of Reproduction. 2011. doi:10.1095/biolreprod.111.097188

Bartol FF, Bagnell CA. Lactocrine programming of female reproductive tract development: Environmental connections to the reproductive continuum. Molecular and Cellular Endocrinology (2011/2012), doi: 10.1016/j.mce.2011.10.008

Cannon MV, Dunn DA, Irwin MH, Brooks AI, Bartol FF, Trounce IA, Pinkert CA.  Xenomitochondrial mice: investigation into mitochondrial compensatory mechanisms.  Mitochondrion 11(1):33-39, 2011.

Chen JC, Frankshun AL, Wiley AA, Miller DJ, Welch KA, Ho TY, Bartol FF, Bagnell CA.  Milk-borne lactocrine-acting factors affect gene expression patterns in the developing neonatal porcine uterus.  Reproduction 141(5):675-683, 2011.

Frankshun AL, Ho TY, Reimer DC, Chen J, Lasano S, Steinetz BG, Bartol FF, Bagnell CA.  Characterization and biological activity of relaxin in porcine milk.  Reproduction 141(3): 373-80 2011.

Mansour M, Schwartz D, Judd R, Akingbemi B, Braden T, Morrison E, Dennis J, Bartol FF, Hazi A, Napier I, Abdel-Mageed AB.  Thiazolidinediones/PPARγ agonists and fatty acid synthase inhibitors as an experimental combination therapy for prostate cancer.  Intl J Oncology 38(2):537-546, 2011.

Chen JC, Wiley AA, Ho TY, Frankshun AL, Hord KM, Bartol FF, Bagnell CA.  Transient estrogen exposure from birth affects uterine expression of developmental markers in neonatal gilts with lasting consequences in pregnant adults.  Reproduction 139(3):623-630, 2010.

Sherrill JD, Sparks M, Dennis J, Mansour M, Kemppainen BW, Bartol FF, Morrison EE, Akingbemi BT.  Developmental exposures of male rats to soy isoflavones impact Leydig cell differentiation.  Biol Reprod 83(3):488-501, 2010.

Bagnell CA, Steinetz BG, Bartol FF. Milk-Borne Relaxin and the lactocrine hypothesis for maternal programming of neonatal tissues.  Annals of the New York Academy of Sciences 1160:152-157, 2009.

Bartol FF, Wiley AA, Bagnell CA.  Relaxin and maternal lactocrine programming of neonatal uterine development.  Annals of the New York Academy of Sciences  1160:158-163, 2009.

Frankshun A, Ho T-Y, Steinetz BG, Bartol FF, Bagnell CA.  Biological activity of relaxin in porcine milk.  Annals of the New York Academy of Sciences 1160:164-168, 2009.

Wiley AA, Kauffold J, Wahner M, Crean-Harris B, Miller DJ, Bagnell CA, Bartol FF.  Laser microdissection of neonatal porcine endometrium for tissue specific evaluation of relaxin receptor (RXFP1) expression in response to perinatal zearalenone exposure.  Annals of the New York Academy of Sciences 1160:190-191, 2009.

Mansour MM, Goyal HO, Braden TD, Dennis JC, Schwartz DD, Judd RL, Bartol FF, Coleman E, Morrison EE.  Activation of penile pro-adipogenic peroxisome proliferator-activated receptor gamma (PPARγ) with an Estrogen: Interaction with estrogen receptor alpha (ERα) during postnatal development.  PPAR Research. 2008. Article ID 651419, 10 pages; doi:10.1155/2008/651419

Bartol FF, Wiley AA, Bagnell CA.  Epigenetic programming of porcine endometrial function and the Lactocrine Hypothesis.  Reproduction in Domestic Animals 43(Suppl 2):273-279, 2008.

Thornhill DJ, Wiley AA, Campbell AL, Bartol FF, Teske A, Halanych KM. Endosymbionts of Siboglinum fiordicum with reference to the phylogeny of Siboglinidae (Annelida) endosymbionts.  The Biological Bulletin 214:135-144, 2008.

Yan W, Chen J, Wiley AA, Crean-Harris BD, Bartol FF, Bagnell CA.  Tissue-specific responses to relaxin in the reproductive tract of newborn gilts and regulation of estrogen receptor alpha, vascular endotheial growth factor and RXFP1 expression by relaxin and estrogen.  Reproduction 135:723-712, 2008.

Masters RA, Crean BD, Moss AG, Yan W, Wiley AA, Bagnell CA, Bartol FF.  Endometrial epithelial proliferative activity and distribution of active beta-catenin in neonatal porcine uterine tissues affected by age and exposure to estrogen and relaxin.  Domestic Animal Endocrinology 33:335-346, 2007.

Yan W, Wiley AA, Bathgate RAD, Frankshu A, Lasano S, Crean BD, Steinetz BG, Bagnell CA, Bartol FF.  Expression of LGR7 and LGR8 by neonatal porcine uterine tissues and transmission of milk-borne relaxin into the neonatal circulation by suckling.  Endocrinology 147:4303-4310, 2006.

Yan W, Ryan PL, Bartol FF, Bagnell CA.  Uterotropic effects of relaxin related to age and estrogen receptor activation in neonatal pigs.  Reproduction 131:943-950, 2006.

Bartol FF, Wiley AA, Bagnell CA. Uterine development and endometrial programming. Society of Reproduction & Fertility Suppl 62: 113-130, 2006.

Gray CA, Bartol FF, Tarleton BJ, Wiley AA, Johnson GA, Bazer FW, Spencer TE.  Developmental biology of uterine glands.  Biology of Reproduction 65:1311-1323, 2001.

Gray CA, Taylor KM, Ramsey WS, Hill JR, Bazer FW, Bartol FF, Spencer TE.  Endometrial glands are required for pre‑implantation conceptus elongation and survival.  Biology of Reproduction 64:1608‑1613, 2001.

Bartol FF, Wiley AA, Floyd JG, Bazer FW, Ott TL, Spencer TE.  Uterine differentiation as a foundation for subsequent fertility.  J Reprod Fertil Supplement 54:285-300, 1999.

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