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Eleanor M. Josephson, DVM, PhD

Associate Professor of Neuroscience and Anatomy, joined the College of Veterinary Medicine in 2000. She received a B.S. in Zoology from the University of Louisville in 1984, and a D.V.M. from Auburn University in 1988. After completing an internship at Rowley Memorial Animal Hospital in Springfield, Massachusetts, she received a Ph.D. in Biomedical Science from Auburn University in 1995. She was a postdoctoral fellow in the lab of Dr. Kent Morest at the University of Connecticut Health Center.

Research Interests

Research Interests:  My research has focused on the anatomical correlates of information processing in the olfactory system. My colleague, Karen Wolfe, and I are using immunoelectron microscopy and light microscopy to make a comparative study of the expression of glutamate signaling molecules, such as NMDA receptors and glutamate uptake proteins, in the olfactory bulbs of mice and dogs. I have also developed a culture system of olfactory epithelium and olfactory bulb tissues that responds to airborne odorants. My colleagues and I hope to use the culture system to study signaling and signal regulation in olfactory receptor neurons and olfactory bulb neurons. On a different topic, I am studying whether web-based technology contributes positively to student performance in the gross anatomy laboratory.

Teaching Responsibilities:  Dr. Josephson is the course coordinator and lectures in Veterinary Neuroanatomy for the Veterinary Neurosciences course for first year veterinary students.  She also teaches a graduate level neuroanatomy course

Selected Publications

Kanju PM, Parameshwaran K, Sims-Robinson C, Uthayathas S, Josephson EM, Rajakumar N, Dhanasekaran M, Suppiramaniam V. Selective cholinergic depletion in medial septum leads to impaired long term potentiation and glutamatergic synaptic currents in the hippocampus. PLoS One 7(2): e31073. doi:10.1371/journal.pone.0031073, 2012.

Viswaprakash N, Josephson E, Dennis J, Yilma S, Morrison E, and Vodyanoy V. Odorant response kinetics from cultured mouse olfactory epithelium at different ages in vitro. Cells, Tissues, Organs 192(6):361-373, 2010.

Viswaprakash N, Dennis JC, Globa L, Pustovyy O, Josephson EM, Kanju P, Morrison EE, Vodyanoy VJ.  Enhancement of odorant-induced responses in ORNs by zinc nanoparticles. Chemical Senses 34:547-557, 2009.

Craven B, Neuberger T, Paterson E, Webb A, Josephson E, Morrison E, Settles G. Reconstruction and morphometric analysis of the nasal airway of the dog and implications regarding olfactory airflow, Anatomical Record 290:1325-1340, 2007.

Josephson EM, Moore LJ. An electronic instructor for gross anatomy dissection. Journal of Veterinary Medical Education 33(3):465-473, 2006.

Josephson EM, Yilma S, Vodyanoy V, Morrison EE. Structure and function of long-lived olfactory organotypic cultures from post-natal mice. Journal of Neuroscience Research 75:642-653, 2004.

Josephson EM, Morest DK. Synaptic nests and glutamate transport in the cochlear nucleus of the mouse. Synapse 49(1):29-46, 2003.

Josephson EM, Morest DK. A quantitative profile of the synapses on the stellate cell body and axon in the cochlear nucleus of the chinchilla. Journal of Neurocytology 27(11):841-864, 1998.

Josephson E, Padgett ML, Buxton DF. The lateral and medial compartments of the rat olfactory tubercle and their relation to olfactory-related input as determined by artificial neural network analysis. Brain Research 744(2):253-271, 1997.

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