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Mahmoud Mansour, DVM, PhD

Associate Professor of Veterinary Anatomy, joined the College of Veterinary Medicine in 2006. He received his Ph.D. from the University of Liverpool in the United Kingdom (1990) and his D.V.M from the University of Khartoum, Sudan (1983). Dr. Mansour received post-doctoral training at Michigan State University where he was a recipient of Fulbright Scholarship (1995). He also received a research training course at the WHO headquarters in Geneva, Switzerland (1993). Dr. Mansour was a member of the faculty at Tuskegee University for several years before joining the faculty at Auburn University.

Research Interests

Currently we are studying the effects of select metabolic and toxic disorders on reproductive function in male subjects. Techniques utilized in the laboratory include RNA extraction, conventional end-point and real time PCR, Western Blotting, and Immunohistochemistry.

Selected Publications

Caitlin Hellmich Trebelhorn, John C. Dennis,  Satya Pondugula, Temesgen Samuel , Elaine Coleman, Patrick Flannery, Edward Morrison , and Mahmoud Mansour. Plant-based omega-3 stearidonic acid (SDA) enhances antitumor activity of doxorubicin (DOX) in human prostate cancer cell lines. J Cancer Res Ther, 2 (9):132-143, 2014.

Mansour, Mahmoud. The Roles of Peroxisome Proliferator-Activated Receptors in the Metabolic Syndrome. In:  Progress in Molecular Biology and Translational Science, Vol. 121, Burlington: Academic Press, ISBN: 978-0-12-800101-1. PP 217-266, 2014.

Mansour M, Steiss J, and Wilhite DR. Equine Anatomy Guide: The Forelimb. Blurb. ISBN 978-0-615-89124-8, 2013.

Hafiz S, Dennis JC, Schwartz D, Judd R, Tao Y-X, Khazal K, Akingbemi B, Mo X-L, Abdel-Mageed AB, Morrison E, and Mansour M.  Expression of melanocortin receptors in human prostate cancer cell lines:  MC2R activation by ACTH increases prostate cancer cell proliferation.  Int J Oncology DOI: 10.3892/ijo.2012.1574

Pfaehler A, Nanjappa MK, Coleman ES, Mansour M, Wanders D, Plaisance EP, Judd RL, Akingbemi BT.  Regulation of adiponectin secretion by soy isoflavones has implication for endocrine function of the testis.  Toxicology Letters 209:78-85, 2012.

Lateef DM, Washington MC, Raboin SJ, Roberson AE, Mansour MM, Williams CS, Sayegh AI.  Duodenal myotomy blocks reduction of meal size and prolongation of intermeal interval by cholecystokinin.  Physiology and Behavior 105:829-834, 2012.

Mansour M, Schwartz D, Judd R, Akingbemi B, Braden T, Morrison E, Dennis J, Bartol FF, Hazi A, Napier I, Abdel-Mageed AB.  Thiazolidinediones/PPARγ agonists and fatty acid synthase inhibitors as an experimental combination therapy for prostate cancer.  Int J Oncology 38(2):537-546, 2011.

Ali MM, Obregon D, Agrawal KC, Mansour M, Abdel-Mageed AB.  Recyclable single-stranded DNA template for synthesis of siRNAs.  BMB Reports 43(11):732-737, 2010.

Washington MC, Murry CR, Raboin SJ, Robertson AE, Mansour MM, Williams CS, Sayegh AI.  Cholecystokinin-8 activates myenteric neurons in 21- and 35-day old but not 4- and 14-day old rats.  Peptides (2010), doi:10.1016/j.peptides.2010.11.010.

Khalil MK, Mansour MM, Wilhite DR.  Evaluation of cognitive loads imposed by traditional paper-based and innovative computer-based instructional strategies.  JVME 37(4):353-357, 2010.

Sherrill JD, Sparks M, Dennis J, Mansour M, Kemppainen BW, Bartol FF, Morrison EE, Akingbemi BT. Developmental exposures of male rats to soy Isoflavones impact Leydig cell differentiation. Biol Reprod. 2010 Jun 10. [Epub ahead of print]PMID: 20554919

Mansour M, White D, Wernette C, Dennis J, Tao Y-X, Collins R, Parker L, Morrison E. Pancreatic neuronal melanocortin-4 receptor modulates serum insulin levels independent of leptin receptor. Endocrine 37:220-230, 2010.

Mansour M, Coleman E, Dennis J, Akingbemi B, Schwartz D, Braden T, Judd R, Plaisance E, Stewart LK, Morrison EE. Activation of PPARy by Rosiglitazone does not negatively impact male sex steroid hormones in diabetic rats. PPAR Res Vol. 2009, Article ID 101857.

Mansour MM, Goyal HO, Braden TD, Dennis JC, Schwartz DD, Judd RL, Bartol F, Coleman ES, Morrison EE. Activation of penile proadipogenic peroxisome proliferator-activated receptor y with an Estrogen: interaction with estrogen receptor alpha during postnatal development. PPAR Res Vol. 2008, Article ID 651419.

Goyal HO, Braden TD, Williams CS, Dalvi P, Mansour M, Williams JW. Estrogen-induced abnormal accumulation of fat cells in the penis and associated loss of fertility depend upon estrogen exposure during critical period of penile development. Toxicol Sci 87:242-254, 2005.

Goyal HO, Braden TD, Williams CS, Dalvi P, Mansour MM, Williams JW. Permanent induction of morphological abnormalities in the penis and penile skeletal muscles in adult rats treated neonatally with diethylstilbestrol or estradiol valerate: A dose-response study. J Andrology 26:32-43, 2005.

Gulley S, Sharma SK, Mansour M, Sullivan CN, Moran TH, Sayegh AI. Strain differences in myenteric neuron number and CCK1 receptor mRNA expression may account for differences in CCK induced c-Fos activation. Brain Research 1058:109.119, 2005.

Goyal HO, Braden TD, Williams CS, Dalvi P, Mansour M, Williams JW, Bartol F, Wiley A, Birch L, Prins G. Abnormal morphology of the penis in male rats exposed neonatally to estrogen is associated with altered profile of estrogen receptor ­alpha protein, but not of androgen receptor protein. A developmental and immunocytochemical study. Biol Reprod 70:1504-1517, 2004.

Mansour MM, Machen MR, Tarleton BJ, Wiley AA, Wower J, Bartol FF, Goyal HO. Expression and molecular characterization of estrogen receptor alpha messenger RNA in male reproductive organs of adult goats. Biol Reprod 64:1432-1438, 2001.

Goyal HO, Braden TD, Mansour M, Williams CS, Kamaleldin A, Srivastava KK. Diethylstilbestrol-treated adult rats with altered epididymal sperm numbers and sperm motility parameters, but without alterations in sperm production and sperm morphology. Biol Reprod 64:927-934, 2001.

Abdelmagid OY, Mansour MM, Okwumabua O, van Drunen Littel-van den Hurk S. Expression and cellular distribution of baculovirus-expressed bovine herpesvirus 1 (BHV-1) glycoprotein D (gD) sequences. Archives of Virology 143:2173-2187, 1998.

Abdelmagid OY, Mansour MM, Minocha HC, van Drunen Littel-van den Hurk S. Evaluation of baculovirus-expressed bovine herpesvirus-1 (BHV-1) glycoproteins for detection and analysis of BHV-1-specific antibody responses. Veterinary Microbiology 61:249-259, 1998.

© 2009 Auburn University College of Veterinary Medicine