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Jennifer R. Panizzi, PhD

Dr. Jennifer R. Panizzi, Assistant Professor in the Department of Anatomy, Physiology, and Pharmacology, joined the Auburn College of Veterinary Medicine faculty in 2013.  A native of Tennessee, Dr. Panizzi received a B.S. degree majoring in both Chemistry and Biology (1998) from Austin Peay State University in Clarksville, TN, then earned her Ph.D. (2007) from Vanderbilt University in Nashville, TN.  Dr. Panizzi continued her training as a postdoctoral fellow in the Nephrology Division at Massachusetts General Hospital/Harvard Medical School in Boston, MA, where she was awarded a Ruth L. Kirschtein National Research Service Award from the National Institutes of Health.

Research Interests

My current research focuses on elucidating the molecular mechanisms underlying cilia motility.  Motile cilia are important for numerous processes within the
vertebrate organism, including circulation of cerebrospinal fluid, clearance of the respiratory tract, sperm motility, and establishment
of the left-right body axis. Of particular interest to my studies is primary
ciliary dyskinesia (PCD), or impaired cilia movement. As many as
1:15000 individuals are estimated to have PCD, which may manifest as chronic respiratory tract infections, infertility, situs reversal, and even cystic kidney
disease. More broadly, the disruption of the signaling functions of cilia have also been observed in relatively more common disorders, including diabetes, polycystic kidney disease, and cancer.  My laboratory utilizes multiple techniques conducted in the zebrafish model system to examine genes that affect ciliary structure and function.

Selected Publications

Austin-Tse C, Halbritter J, Zariwala MA, Gilberti RM, Gee HY, Hellman N, Pathak N, Liu Y, Panizzi JR, Patel-King RS, Tritscher D, Bower R, O'Toole E, Porath J, Hurd TW, Chaki M, Diaz KA, Kohl S, Lovric S, Braun DA, Schueler M, Airik R, Otto EA, Leigh MW, Noone PG, Carson JL, Davis SD, Pittman JE, Ferkol TW, Atkinson JJ, Olivier KN, Sagel SD, Dell SD, Rosenfeld M, Milla CE, Porter ME, King SM, Knowles MR, Drummond IA, and Hildebrandt F.  A Ciliopathy Screen in Zebrafish Coupled With Human Mutational Analysis Identifies C21orf59 and CCDC65 Defects as Causing Primary Ciliary Dyskinesia. American Journal of Human Genetics 93(4):672-686, 2013.

Panizzi JR, Becker-Heck A, Castleman VH, Al-Mutairi D, Liu Y, Loges NT, Austin-Tse C, Sheridan E, Schmidts M, Olbrich H, Werner C, Häffner K, Hellman NE, Chodhari R, Gupta A, Kramer-Zucker A, Olale F, Burdine R, Schier AF, O'Callaghan C, Chung EMK, Reinhardt R, Mitchison HM, King SM, Omran H, and Drummond IA.  CCDC103 Mutations Cause Primary Ciliary Dyskinesia by Disrupting Assembly of Ciliary Dynein Arms. Nature Genetics 44(6):714-719, 2012.

Panizzi P, Nahrendorf M, Figueiredo JL, Panizzi JR, Marinelli B, Iwamoto Y, Keliher E, Maddur AA, Waterman P, Kroh HK, Leuschner F, Aikawa E, Swirski FK, Pittet MJ, Hackeng TM, Fuentes-Prior P, Schneewind O, Bock PE, and Weissleder R. In Vitro Detection of Staphylococcus aureus Endocarditis by Targeting Pathogen-Specific Prothrombin Activation. Nature Medicine 17(9):1142-1146, 2011.

Lin F, Chen S, Sepich DS, Panizzi JR, Clendenon SG, Marrs JA, Hamm HE, and Solnica-Krezel L. Ga12/13 Regulate Epiboly by Inhibiting E-cadherin Activity and Modulating the Actin Cytoskeleton. J Cell Biol 184(6):909-921, 2009.

Panizzi JR, Jessen JR, Drummond IA, and Solnica-Krezel L. New Functions for a Rho Guanine Nucleotide Exchange Factor in Ciliated Epithelia. Development 134(5):921-931, 2007

Kozak KR, Crews BC, Ray JL, Tai HH, Morrow JD, and Marnett LJ. Metabolism of Prostaglandin Glycerol Esters and Prostaglandin Ethanolamides in vitro and in vivo. J Biol Chem 276(40):36993-36998, 2001.

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