My current research focuses on elucidating the molecular mechanisms underlying cilia motility. Motile cilia are important for numerous processes within the vertebrate organism, including circulation of cerebrospinal fluid, clearance of the respiratory tract, sperm motility, and establishment of the left-right body axis. Of particular interest to my studies is primary ciliary dyskinesia (PCD), or impaired cilia movement. As many as 1:15000 individuals are estimated to have PCD, which may manifest as chronic respiratory tract infections, infertility, situs reversal, and even cystic kidney disease. More broadly, the disruption of the signaling functions of cilia have also been observed in relatively more common disorders, including diabetes, polycystic kidney disease, and cancer. My laboratory utilizes multiple techniques conducted in the zebrafish model system to examine genes that affect ciliary structure and function.