The laboratory has interests in understanding the role of nuclear receptors (NRs), including pregnane xenobiotic receptor (PXR), in health and disease. It has been shown that PXR plays a central role in activating the expression of drug metabolizing enzymes. Changes in the expression of PXR-regulated drug metabolizing enzymes may lead to adverse drug interactions. The more recent evidence also suggests that PXR has implications in cancer pathogenesis, chemotherapeutic drug resistance, and endocrine disruption. However, the cellular mechanisms that regulate PXR activity are poorly understood. We will investigate the mechanisms regulating PXR activity by using modern molecular and cell biology approaches.