Satyanarayana R. Pondugula, DVM, PhD

112 Greene Hall

Phone: 334-844-8505 (office); 334-844-7668 (lab)

Email: srp0010@auburn.edu

Dr. Satyanarayana R. Pondugula, Assistant Professor in the Department of Anatomy, Physiology and Pharmacology, joined Auburn University in August 2011. He earned his DVM from the College of Veterinary Science in Tirupati, India, and his PhD from Kansas State University in Manhattan, KS. He continued his training as a postdoctoral fellow at St Jude Children’s Research Hospital in Memphis, TN.

Research Interests

Research Interests:  My laboratory has interests in understanding the role of nuclear receptors, including pregnane X receptor, in health and disease. Specifically, our research is focused on understanding the mechanisms of pregnane X receptor mediated adverse drug interactions and chemoresistance. Additionally, our collaborative research efforts are focused on identifying modulators of pregnane X receptor to prevent adverse drug interactions and/or chemoresistance. We are also interested in discovering novel natural products and small molecules to chemosensitize difficult to treat cancers.


Teaching Responsibilities:  I participate in teaching team-taught Veterinary Anatomy II and Cell Physiology & Molecular Genetics courses to the first year veterinary students. I also take part in teaching team-taught Endocrinology and Receptorology courses to graduate students.

Selected Publications

Pondugula SR, Flannery PC, Abbott KL, Coleman ES, Mani S, Samuel T, Xie W. Diindolylmethane, a naturally occurring compound, induces CYP3A4 and MDR1 gene expression by activating human PXR. Toxicol Lett (In Press).

Karthikeyan C, Lee C, Moore J, Mittal R,  Suswam EA, Abbott KL, Pondugula SR, Manne U, Narayanan NK, Trivedi P, Tiwari AK. IND2, a pyrimido[1,2 :1,5]-pyrazolo[3,4-b]quinoline derivative, circumvents multi-drug resistance and causes apoptosis in colon cancer cells. Bioorg Med Chem (In Press).

Pondugula SR, Flannery PC, Apte U, Babu JR, Geetha T, Rege SD, Chen T, Abbott KL. PPM1A phosphatase regulates PXR-mediated CYP3A4 gene expression. Drug Metab Dispos (In Press).

Trebelhorn CH, Dennis JC, Pondugula SR, Samuel T, Coleman ES, Flannery P. Morrison E, Mansour M. Plant-based omega-3 stearidonic acid enhances antitumor activity of doxorubicin in human prostate cancer cell lines. J Cancer Res Ther 2(9):132-143, 2014.

Pondugula SR, Kampalli SB, Wu T, De Lisle RC, Raveendran NN, Harbidge DG, Marcus DC. cAMP-stimulated Cl- secretion is increased by glucocorticoids and inhibited by bumetanide in semicircular canal duct epithelium. BMC Physiol Mar 27;13:16, 2013.

Pondugula SR, Mani S. Pregnane xenobiotic receptor in cancer pathogenesis and therapeutic response. Cancer Lett Jan 1;328(1):1-9, 2013.

Pondugula SR, Tong A, Wu J, Cui J, Chen T. Protein phosphatase 2Cβl regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells. Drug Metab Dispos Sep;38(9):1411-1416, 2010.

Pondugula SR, Dong H, Chen T. Phosphorylations and protein-protein interactions in PXR-mediated CYP3A Repression. Expert Opin Drug Metab Toxicol Aug;5(8):861-873, 2009.

Pondugula SR, Brimer-Cline C, Wu J, Schuetz EG, Tyagi RK, Chen T. A phosphomimetic mutation at threonine-57 abolishes transactivation activity and alters nuclear localization pattern of human pregnane X receptor. Drug Metab Dispos Apr;37(4):719-730, 2009.

Kim SH, Kim KX, Raveendran NN, Wu T, Pondugula SR, Marcus DC. Regulation of Epithelial Sodium Channel (ENaC)-Mediated Sodium Transport by Glucocorticoids in Reissner's Membrane Epithelium. Am J Physiol Cell Physiol Mar;296(3):C544-C557, 2009.

Pondugula SR, Raveendran NN, Ergonul Z, Deng Y, Chen J, Sanneman JD, Palmer LG, Marcus DC. Glucocorticoid-regulation of genes in the amiloride-sensitive sodium transport pathway by semicircular canal duct epithelium of neonatal rat.  Physiol Genomics Jan 12;24(2):114-123, 2006.

Pondugula SR, Sanneman JD, Wangemann P, Milhaud PG, Marcus DC.  Glucocorticoids stimulate cation absorption by semicircular canal duct epithelium via epithelial sodium channel.  Am J Physiol Renal Physiol Jun; 286(6):F1127-F1135, 2004.

Milhaud PG, Pondugula SR, Lee JH, Herzog M, Lehouelleur J, Wangemann P, Sans A, Marcus DC.  Chloride secretion by semicircular canal duct epithelium is stimulated via β2-adrenergic receptors. Am J Physiol Cell Physiol Dec; 283(6):C1752-C1760, 2002.