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James L. Sartin, MS, PhD

Professor of Physiology in the Department of Anatomy, Physiology and Pharmacology and the Department of Animal Health Research, Alabama Agricultural Experiment Station, joined the College of Veterinary Medicine in 1982. He received his BA in Psychology from Auburn University in 1973, MS in Zoology from Auburn University in 1976 and a PhD in Physiology from Oklahoma State University in 1978. He was a Teaching Associate at Oklahoma State from 1978-1979 before beginning postdoctoral training at Temple University from 1979-1981. Dr. Sartin spent an additional year on the faculty at Temple University. Dr. Sartin was editor of Domestic Animal Endocrinology from 1984-2008. He is a member of the Board of Directors of the American Society of Animal Science (ASAS; 2008-2010) and was awarded the Animal Growth and Development Research Award in 2008 by the ASAS.

214 Greene Hall
334-844-4425
sartijl@auburn.edu

Research Interests

Primary research and teaching interests are in the area of endocrinology. The general thrust of research has been in the area of control of appetite in sheep, particularly orexin, neuropeptide Y, melanin concentrating hormone and AGRP. The role of disease in appetite suppression and the effects of kisspeptin to regulate GH release are the current projects.

Selected Publications

Hudman A, G Davenport, ES Coleman, and JL Sartin. (2009) Low doses of estradiol partly inhibit release of GH in sheep wihtout affecting basal levels. Domesitc Animal Endocrinology (in press).

Sartin JL, DL Marks, CD McMahon, JA Daniel, P Levasseur, CG Wagner, BK Whitlock and BP Steele.  (2008)  Central role of melanocortin-4 receptors in appetite regulation following endotoxin. Journal of Animal Science 86:2557-2567.

Whitlock BK, JA. Daniel, RR Wilborn, SP. Rodning, HS Maxwell, BP Steele, JL Sartin.  (2008)  Interaction of estrogen and progesterone on kisspeptin stimulated luteinizing hormone and growth hormone in ovariectomized cows.  Neuroendocrinology 88:212-215.

Whitlock, BK, J Daniel, RR Wilborn, TH Elsasser, JA Carroll and JL Sartin.  (2008)  Comparative aspects of endotoxin- and cytokine-induced endocrine cascade influencing growth, metabolism and reproduction in farm mammals. Reproduction in Domestic Animals 43: (Suppl. 2, in press).

Elsasser TH, TJ Caperna, C-J Li, S Kahl and JL Sartin.  (2008)  Critical control points in the impact of proinflammatory immune response on growth and metabolism. Journal of Animal Science 86(E Suppl):E105-125.

Fan Z-C, JL Sartin, Y-X Tao.  (2008)  Pharmacological Analysis of Two Naturally Occurring Porcine Melanocortin-4 Receptor Mutations in Domestic Pigs. Domestic Animal Endocrinology 34:383-390.

Fan Z-C, JL Sartin, Y-X Tao.  (2008)  Molecular cloning and pharmacological characterization of porcine melanocortin-3 receptor. Journal of Endocrinology 196, 139-148.

Elsasser TH, S Kahl, C-J Li, JL Sartin, WM Garrett, J Rodrigo.  (2007)  Caveolae nitration of JAK-2 at the 1007Y-1008Y site: Coordinating inflammatory response and metabolic hormone readjustment within the somatotropic axis. Endocrinology 148:3792-3802.

Elsasser TH, TJ Caperna, PJ Ward, JL Sartin, BP Steele, C Li, S Kahl. (2007)  Mechanisms regulating growth factor activity during proinflammatory stress:  cytokine modulation of IGF binding proteins released by cultured bovine kidney epithelial cells. Domestic Animal Endocrinology 33:390-399.

Obese FY, BK Whitlock, BP Steele, FC Buonomo, JL Sartin.  (2007)  Long-term food intake regulation in sheep is mediated by opioid receptors.  Journal of Animal Science 85:111-117.

C Xiao, J Sartin, JJ Mulchahey, T Segar, S Sheriff, JP Herman, JW Kasckow.  (2006)  Aging associated changes in amygdalarcorticotropin-releasing hormone (CRH) and CRH-binding protein in Fisher 344 rats.  Brain Research 1073-1074:325-331.

Daniel JA, TH Elsasser, A Martinez, B Steele, JL Sartin.  (2005)  Interleukin-1 and tumor necrosis factor mediation of endotoxin actionon growth hormone.  American Journal of Physiology:  Endocrinology and Metabolism 289: E650-E657.

Sartin JL, CG Wagner, DL Marks, J Daniels, CD McMahon, FY Obese, C Partridge. (2005)  Appetite regulation in sheep: a potential site for therapeutic intervention in disease models.  Domestic Animal Endocrinology 29:446-455.

BK Whitlock, JA Daniel, CD McMahon, FC Buonomo, CG Wagner, B Steele, JL Sartin.  (2005)  Intracerebroventricular melanin-concentrating hormone stimulates food intake in sheep.  Domestic Animal Endocrinology 28:224-232.

Wagner CG, CD McMahon, DL Marks, JA Daniel, JL Sartin.  (2004)  A role forAGRP in appetite regulation in a species with continuous nutrient delivery. Neuroendocrinology 80:210-218.

Elsasser TH, S Kahl , C MacLeod, B Nicholson, JL Sartin, C Li.  (2004)  Mechanisms underlying growth hormone effects In augmenting nitric oxide production and protein tyrosine nitration during endotoxin challenge. Endocrinology 145:3413-3423.

Daniel JA, TH Elsasser, CD Morrison, DH Keisler, BK Whitlock, B Steele, D Pugh, JL Sartin.  (2003)  Localization of leptin, tumor necrosisfactor-a, and CD14 in ovine adipose and changes in circulating TNF inlean and obese sheep. Journal of Animal Science 81:2590-2599.

Sartin JL, TH Elsasser, S Kahl, J Baker, JA Daniel, DD Schwartz, B Steele, BK Whitlock.  (2003)  Estradiol and progesterone treatment modulates select elements of the proinflammatory cytokine cascade: Attenuated nitric oxide and thromboxane B2 production in endotoxemia. Journal of Animal Science 81:1546-1551.

Daniel JA, BK Whitlock, CG Wagner, JL Sartin.  (2002)  Regulation of growth hormone and luteinizing hormone response to endotoxin in sheep. Domestic Animal Endocrinology 22: 361-370, 2002.

Daniel JA, BK Whitlock, JA Baker, B Steele, CD Morrison, DH Keisler, JL Sartin.  (2002)  Effect of body fat mass and nutritional status on 24-hour leptin profiles in ewes. Journal of Animal Science 80:1083-1089.

Sartin JL, C Dyer, R Matteri, D Buxton, F Buonomo, M Shores, J Baker, JA Osbourne, T Braden, B Steele.  (2001)  Effect of intracerebroventricular orexin-B on food intake in sheep.  Journal of Animal Science 79:1573-1577.

McMahon, CD, DF Buxton, TH Elsasser, DR Gunter, LG Sanders, BP Steele, JL Sartin.  (1999)  Neuropeptide Y restores appetite and alters concentrations of growth hormone (GH) after central administration to endotoxic sheep.  Journal of Endocrinology 161:333-339.

McMahon, CD, TH Elsasser, DR Gunter, LG Sanders, BP Steele and JL Sartin.  (1998) Estradiol/progesterone implants increase food intake, reduce hyperglycemia and increase insulin resistance in endotoxic steers. Journal of Endocrinology159: 469-478, 1998.

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