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Dean D. Schwartz, PhD

Associate Professor of Physiology, joined the College of Veterinary Medicine in October, 1993. He received his B.S. in biology from Stonehill College in 1980 and his Ph.D. from the University of Houston College of Pharmacy in 1987. Dr. Schwartz’s postdoctoral training was carried out at the University of Tennessee, Memphis, where he was a fellow of the Hypertension Training Grant before obtaining funding from the American Heart Association Tennessee Affiliate and the National Institutes of Health.

 

Research Interests

The primary research interests of my laboratory are in the area of cardiovascular pharmacology and stress-induced changes in gene expression and function. Current research projects include 1) Role of endothelin in diabetic cardiomyopathy; 2) Heat-stress induced alterations in brain gene expression; 3) Cardiovascular effects of methylmercury and N-3 fatty acids and; 4) Clinical effects of renal dopamine receptors.

Selected Publications

Mansour M, Schwartz D, Judd R, Akingbemi B, Braden T, Morrison E, Dennis J, Bartol FF, Hazi A, Napier I, Abdel-Mageed AB.  Thiazolidinediones/PPARγ agonists and fatty acid synthase inhibitors as an experimental combination therapy for prostate cancer.  Intl J Oncology 38(2):537-546, 2011.

Ding Y, Schwartz DD, Posner P, Zhong J. Hypotonic swelling stimulates L-type Ca2+ channel activity in vascular smooth muscle cells through PKC. Am J Physiol Cell Physiol 287:C413-C421, 2004.

Evans RK, Schwartz DD, Gladden LB. Effect of myocardial volume overload and heart failure on lactate transport into isolated cardiac myocytes. J Appl Physiol 94(3):1169-1176, 2003.

Sartin JL, Elsasser TH, Kahl S, Baker J, Daniel JA, Schwartz DD, Steele B, Whitlock BK. Estradiol plus progesterone treatment modulates select elements of the proinflammatory cytokine cascade in steers: attenuated nitric oxide and thromboxane B2 production in endotoxemia. J Anim Sci 81(6):1546-1551, 2003.

Flournoy WS, Wohl JS, Albrecht-Schmitt TJ, Schwartz DD. Pharmacologic identification of putative D1 dopamine receptors in feline kidneys. J Vet Pharmacol Ther 26(4):283-290, 2003.

Evans RK, Schwartz DD, Gladen LB. Effect of myocardial volume overload and congestive heart failure on lactate transport into isolated ventricular cardiac myocytes. J Appl Physiol 94 (3):1169-1176, 2003.

Zhong QZ, Lin CY, Clarke KJ, Kemppainen RJ, Schwartz DD, Judd RL. Endothelin-1 inhibits resistin secretion in 3T3-L1 adipocytes. Biochemical and Biophysical Research Communications 296(2):383-387, 2002.

Sartin JL, Shores MA, Schwartz DD, Kemppainen RJ, Baker J. Reduced growth of calves and its reversal by use of anabolic agents. Domestic Animal Endocrinology 19:85-92, 2000.

Wohl JS, Schwartz DD, Flournoy WS. Renal hemodynamics and diuretic effects of low-dose dopamine in the cat. Proceedings, Seventh International Veterinary Emergency and Critical Care Symposium, Orlando, Florida, pp 14-24, 2000.

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