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Dean D. Schwartz, PhD

Associate Professor of Physiology, joined the College of Veterinary Medicine in October, 1993. He received his B.S. in biology from Stonehill College in 1980 and his Ph.D. from the University of Houston College of Pharmacy in 1987. Dr. Schwartz’s postdoctoral training was carried out at the University of Tennessee, Memphis, where he was a fellow of the Hypertension Training Grant before obtaining funding from the American Heart Association Tennessee Affiliate and the National Institutes of Health.

 

Research Interests

The primary research interests of my laboratory are in the areas of cardiovascular pharmacology and oxidative stress. Current research projects include redox-sensitive MRI contrast agents, cardiovascular effects of antioxidants in diabetes, role of NADPH oxidases in equine laminitis. 

Selected Publications

Salter MM, Seeto WJ, DeWitt BB, Hashimi S, Schwartz DD, Lipke EA, Wooldridge AA.  Characterization of endothelial colony forming cells from peripheral blood samples of adult horses.  American Journal of Veterinary Research, AJVR-14-07-0188.R1.  (In Press)

Norton EM, Wooldridge AA, Stewart AJ, Cusimano L, Schwartz DD, Johnson C, Boudreaux M, Christopherson PW, Mutational analysis and factor VIII sequence in a colt with hemophilia A, Veterinary Clinical Pathology. (In Press)

Yu M, Ambrose S, Whaley Z, Fan S, Gorden J, Beyers R, Schwartz D, Goldsmith C.  A mononuclear manganese(II) complex with the capability to simultaneously image and treat oxidative stress.  Journal of the American Chemical Society DOI: 10.1021/ja507034d; 136(37):12836–12839, 2014.

Wooldridge AA, Waguespack RW, Schwartz DD, Venugopal CS, Eades SC, Beadle RE.   Vasorelaxation response to insulin in laminar vessel rings from healthy, lean horses. The Veterinary Journal 202(1):83-88, 2014.

Lohani M, Ahuja M, Schwartz D, Shannon D, Romando A, Kemppainen B, Dhanasekaran M.  Anti-oxidative and DNA protecting effects of flavonoids rich Scutellaria lateriflora, Natural Product Communications, 8(10), 1415-1418, 2013.

Hafiz S, Dennis JC, Schwartz D, Judd R, Tao YX, Khazal K, Akingbemi B, Mo XL, Abdel-Mageed AB, Morrison EE, Mansour M.  Expression of melanocortin receptors in human prostate cancer cell lines: MC2R activation by ACTH increases prostate cancer cell proliferation. International journal of oncology. DOI: 10.3892/ijo.2012.1574, 2012.

El-Orabi NF, Rogers CB, Edwards HG, and Schwartz DD.  Heat-induced inhibition of superoxide dismutase and accumulation of reactive oxygen species leads to HT-22 hippocampal cell death. Journal of Thermal Biology, Volume, 36(1), 49-56, 2011.

Mansour M, Schwartz D, Judd R, Akingbemi B, Braden T, Morrison E, Dennis J, Bartol FF, Hazi A, Napier I, Abdel-Mageed AB.  Thiazolidinediones/PPARγ agonists and fatty acid synthase inhibitors as an experimental combination therapy for prostate cancer.  Intl J Oncology 38(2):537-546, 2011.

Fisher G, Schwartz DD, Quindry JC, Barberio MD, Foster EB 2nd, Jones KW, Pascoe DD. Lymphocyte Enzymatic Antioxidant responses to oxidative stress following high-intensity interval exercise. J Appl Physiol 110:730-737, 2011.

Ding Y, Schwartz DD, Posner P, Zhong J. Hypotonic swelling stimulates L-type Ca2+ channel activity in vascular smooth muscle cells through PKC. Am J Physiol Cell Physiol 287:C413-C421, 2004.

Evans RK, Schwartz DD, Gladden LB. Effect of myocardial volume overload and heart failure on lactate transport into isolated cardiac myocytes. J Appl Physiol 94(3):1169-1176, 2003.

Sartin JL, Elsasser TH, Kahl S, Baker J, Daniel JA, Schwartz DD, Steele B, Whitlock BK. Estradiol plus progesterone treatment modulates select elements of the proinflammatory cytokine cascade in steers: attenuated nitric oxide and thromboxane B2 production in endotoxemia. J Anim Sci 81(6):1546-1551, 2003.

Flournoy WS, Wohl JS, Albrecht-Schmitt TJ, Schwartz DD. Pharmacologic identification of putative D1 dopamine receptors in feline kidneys. J Vet Pharmacol Ther 26(4):283-290, 2003.

Evans RK, Schwartz DD, Gladen LB. Effect of myocardial volume overload and congestive heart failure on lactate transport into isolated ventricular cardiac myocytes. J Appl Physiol 94 (3):1169-1176, 2003.

Zhong QZ, Lin CY, Clarke KJ, Kemppainen RJ, Schwartz DD, Judd RL. Endothelin-1 inhibits resistin secretion in 3T3-L1 adipocytes. Biochemical and Biophysical Research Communications 296(2):383-387, 2002.

Sartin JL, Shores MA, Schwartz DD, Kemppainen RJ, Baker J. Reduced growth of calves and its reversal by use of anabolic agents. Domestic Animal Endocrinology 19:85-92, 2000.

Wohl JS, Schwartz DD, Flournoy WS. Renal hemodynamics and diuretic effects of low-dose dopamine in the cat. Proceedings, Seventh International Veterinary Emergency and Critical Care Symposium, Orlando, Florida, pp 14-24, 2000.

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