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Vitaly J. Vodyanoy, MS, PhD

Professor of Physiology and Director of Biosensor Laboratory, joined the College of Veterinary Medicine in 1989. Dr. Vodyanoy received his M.S. in Physics from Moscow Physical Engineering Institute in 1964, and his Ph.D. in biophysics in 1973 from Agrophysical Research Institute, Leningrad, USSR. He has been a member of the faculty in the Institute of Semiconductors and A.F. Loffe Physicotechnical Institute, Academy of Sciences, Leningrad, USSR. He had worked at the Department of Chemistry, New York University and the Department of Physiology and Biophysics, College of Medicine, University of California, Irvine.

Research Interests

Sensory physiology, receptors, cancer cells, biosensors, cell membranes,  monolayers and bilayers, molecular recognition, olfactory receptor neurons, nanoparticles, biopolymers, bacteriophages, primo-vascular system, and light microscopy. The major research aims are to determine the initial chemoreceptive events in the animal olfactory system and to find out how is odorant information translated into electrical events in the olfactory receptor. The work involves zinc metal nanoparticles that we found strongly enhance olfactory sensory neuron responses to odorants.  Another focus of our research is centered in structural properties of primo nodes, vessels, and capillaries that are being characterized by a high resolution light microscopy. We presume that knowledge of the primo vascular system, that may represent acupuncture meridians, offers advances in medical science comparable to the progress generated by the lymphatic system’s discovery. We also work with a novel cell preservation process and biopolymer which is non-toxic, water-soluble, allows for the storage of samples without refrigeration.  Finally, we are developing biosensors that are based on bacteriophages targeting pathogenic bacteria.

Selected Publications

Krumnov AA, Sorokulova IB, Olsen E, Globa L, Barbaree JM, Vodyanoy VJ. Preservation of bacteria in natural polymers. Journal of Microbiological Methods 78(2):189-194, 2009.

Sorokulova IB, Krumnow AA, Suram P, Mandell AJ, Vodyanoy V. Novel methods for storage stability and release of Bacillus spores. Boitechnology Progress 24(5):1147-1153, 2008.

Guntupalli R, Sorokulova I, Krumnow A, Pustovyy O, Olsen E, Vodyanoy V. Real-time optical detection of methicillin-resistant Staphylococcus aureus using lytic phage probes. Biosens Bioelectron 24(1):151-154, 2008.

Olsen EV, Sykora JC, Sorokulova IB, Chen I-H, Neely WC, Barbaree JM, Petrenko VA, Vodyanoy VJ. Phage fusion proteins as bioselective receptors for piezoelectric sensors. ECS Transactions 2(19):9-25, 2007.  

Nanduri V, Sorokulova IB, Samoylov AM, Simonian AL, Petrenko VA, Vodyanoy V. Phage as a molecular recognition element in biosensors immobilized by physical adsorption. Biosens Bioelectron 22(6):986-992, 2007. 

Balasubramanian S, Sorokulova IB, Vodyanoy VJ, Simonian AL. Lytic phage as a specific and selective probe for detection of Staphylococcus aureus-A surface plasmon resonance spectroscopic study. Biosens Bioelectron 22(6):948-955, 2007.

Samoylov AM, Samoylova TI, Pustovyy OM, Samoylov AA, Toivio-Kinnucan MA, Morrison NE, Globa LP, Gale WF, Vodyanoy V. Novel metal clusters isolated form blood are lethal to cancer cells. Cells, Tissues Organs 179(3):115-124, 2005.

Samoylov AM, Samoylova TI, Pustovyy OM, Samoylov AA, Toivio-Kinnucan MA, Morrison NE, Globa LP, Gale WF, Vodyanoy V. Anti-tumor extracts isolated from shark tissue. Molecular Biology of the Cell 15:253A-253A 1398 Suppl. S, 2004.

Sykora JC, Neely WC, Vodyanoy V. Thermodynamic characteristics of mixed monolayers of Amphotericin B and cholesterol. Journal of Colloid and Interface Science 276(1):60-67, 2004.

Josephson EM, Yilma S, Vodyanoy V, Morrison EE. Structure and function of long-lived olfactory organotypic cultures from postnatal mice. Journal of Neuroscience Research 75(5):642-653, 2004.

Sykora JC, Neely WC, Vodyanoy V. Solvent effects on Amphotericin B monolayers. Journal of Colloid and Interface Science 269(2):499-502, 2004.

Olsen EV, Pathirana ST, Samoylov AM, Barbaree JM, Chin BA, Neely WC, Vodyanoy V. Specific and selective biosensor for Salmonella and their detection in the environment. The Journal of Microbiological Methods 53(2):273-285, 2003.

Sykora J, Yilma S, Neely WC, Vodyanoy V. Amphotericin B and cholesterol in monolayers and bilayers. Longmuir 19:858-864, 2003.

Petrenko VA, Vodyanoy VJ. Phage display for detection of biological threat agents. The Journal of Microbiological Methods 53:253-262, 2003.

For a complete list of publications, visit

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