Juming Zhong, DVM, PhD

Associate Professor of Veterinary Histology, joined the College of Veterinary Medicine in 2001. He received his DVM from China in 1982 and his PhD in Physiology from University of Missouri in 1995.  He was a postdoctoral fellow with Drs. Joseph Hume and Kathleen Keef at University of Nevada School of Medicine and was promoted to a Research Assistant Professor there in 1999.

Research Interests

The research interests of my laboratory include cardiac and vascular smooth muscle electrophysiology and pharmacology. One of the primary goals of my research is to investigate the signaling pathways underlying ion channel regulation in both cardiac and vascular smooth muscle cells under normal and pathophysiological conditions. Ion channels play a center role in the excitation-contraction coupling of these cells, and thus directly control cardiac function and vascular tone. Abnormal activity of these channels directly contributes to the heart diseases and abnormal blood pressure. Application of patch clamp technique allows us to study these channels in the freshly isolated cardiac and vascular smooth muscle cells. Another primary focus of my laboratory is to investigate the cellular mechanisms underlying myocardial dysfunction resulted from various patho-physiological conditions. Specifically, we try to understand the mechanisms that influence intracellular calcium homeostasis and cell contraction of cardiac myocytes taken from different animal disease models.

Teaching Responsibilities:  Dr. Zhong’s teaching responsibilities include course coordinator and instruction in Basic Microanatomy of Domestic Animals (Microanatomy I), and assist in instruction of Organology of Domestic Animal (Microanatomy II) to first year veterinary medical students and graduate study.

Selected Publications

Ding Y, Zou R, Judd RL, Zhong J. Endothelin-1 receptor blockade prevented the electrophysiological dysfunction in cardiac myocytes of streptozotocin-induced diabetic rats. Endocrine 30:121-127, 2006.

Callaghan B, Zhong J, Keef KD. Signaling pathway underlying stimulation of L-type Ca2+ channels in rabbit portal vein myocytes by recombinant Gbgsubunits. Am J Physiol Heart Circ Physiol 291:H2541-H2546, 2006.

Ding Y, Zou R, Judd RL, Zhong J. Effects of gender difference on cardiac myocyte dysfunction in type-1 diabetic rats. Endocrine 29:135-141, 2006.

Banerjee S, Curto EV, Beckman M, Brown GB, Zhong JKrishna NR. Expression of functional scorpion neurotoxin Lqq-V in E.coli. Peptides 27:49-54, 2006.

Ding Y, Zou R, Judd RL, Schwartz DD, Zhong J. Contribution of Endothelin-1 in cardiac myocyte dysfunction in type-1 diabetic rats. J Card-Renal Res 1:23-32, 2006.

Ding Y, Schwartz DD, Posner P, Zhong J. Hypotonic swelling increases L-type calcium channel activity in rabbit portal vein smooth muscle cells through protein kinase C.  Am J Physiol 287:C413-C421, 2004.

Wang G-X, Hatton WJ, Wang GL, Zhong J, Yamboliev I, Duan D, Hume JR. Functional effects of novel anti-ClC-3 antibodies on native volume-sensitive osmolyte and anion channels in cardiac and smooth muscle cells. Am J Physiol 285:H1453-H1463, 2003.

Zhong J, Wang GX, Hatton WJ, Yamboliev IA, Walsh MP, Hume JR. Regulation of volume-sensitive outwardly rectifying anion channels in pulmonary arterial smooth muscle cells by protein kinase C. Am J Physiol 283:C1627-C1636, 2002.

Keef KD, Hume JR, Zhong J. Regulation of cardiac and smooth muscle Ca2+ channels (Cav1a,b) by protein kinases. Am J Physiol 281:C1743-1756, 2001.

Zhong J, Dessauer CW, Keef KD, Hume JR. Regulation of L-type Ca2+ channels in rabbit portal vein by G-protein ?s and ?? subunits. J Physiol 517:109-120, 1999.

Zhong J, Hwang T-C, Adams HR, Rubin LJ. Reduced L-type calcium current in ventricular myocytes isolated from endotoxemic guinea pigs. Am J Physiol 273:H2312-H2324, 1997.

Zhong J, Adams HR, Rubin LJ. Cytosolic Ca2+ concentration and contraction-relaxation properties of ventricular myocytes from E. Coli endotoxemic guinea pigs. Shock 7:383-388, 1997.

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