Annette N. Smith, DVM, MS, DACVIM


Dr. Smith completed 3 years of a Biomedical Science program at Texas A&M prior to admission to the DVM program at Texas A&M's College of Veterinary Medicine. She graduated with honors in May 1994.

Her interest in internal medicine and oncology had been piqued as a senior veterinary student, and during her internship at the University of Illinois, she decided to pursue residency training in both specialties, and joined Auburn University's program in 1995. She was certified in both internal medicine and oncology in May 2000.

While pusuing her residency training, she also completed requirements for a Master's degree in Biomedical Sciences, and received her diploma in December 2001.

She served on the Auburn University faculty as an assistant Clinical Professor from 1999-2000, an Assistant Professor from 2000-2005, an Associate Professor from 2005-2012, and is currently a  Full Professor.

She coordinates Auburn University's oncology program, which focuses on a multidisciplinary team approach to each patient. She is also a founding member of the Auburn University Research Initiative in Cancer (AURIC)'s board, which promotes the concept of One Medicine.

Research Interests

Angiogenesis, hemangiosarcoma, thymoma, intracavitary chemotherapy, gene therapy for osteosarcoma and lymphosarcoma.

Selected Publications

  • Back A, Schleis S, Smrkovski O, Smith A, Lee J, Phillips J. Mechlorethamine, vincristine, melphalan, and prednisone (MOMP) for the treatment of relapsed lymphoma in dogs. Accepted Vet Comp Oncol 6/18/2013.
  • Graff E, Spangler EA, Smith AN. Hematologic findings predictive of bone marrow disease in dogs with multicentric large cell lymphoma. Accepted Vet Clin Pathol 2013.
  • Sones E, Smith A, Schleis S, Brawner W, Almond G, Taylor K, Haney S, Wypij J, Keyerleber M, Arthur J, Hamilton T, Lawrence J, Gieger T, Sellon R, Wright Z. Canine intranasal sarcomas treated with radiation therapy: 86 cases (1996-2011). Vet Radiol and Ultrasound 2013; doi: 10.1111/vru.12006
  • Aubry OA, Spangler EA, Schleis SE, Smith AN. Evaluation of bone marrow aspirates from multiple sites for staging of canine lymphoma and mast cell tumors. Vet Comp Oncol 2012; doi: 10.1111/j.1476-5829.2012.00331.x
  • Merrick C, Smith AN, Schleis SE, Mallett C, Graff E, Weiss R. Hypercalcemia of malignancy associated with renal cell carcinoma in a dog. Accepted J Am Animal Hosp Assoc 1/3/2012.
  • Brugmann BL, Smith AN, Lee HP, Boothe DM, Higginbotham ML, Whitley EM, Smith BF, Behrend EN. In vitro evaluation of ABCB1 after exposure to prednisolone and enrofloxacin in two canine lymphoid cell lines: A pilot study. Internat J Applied Research in Vet Med 2012;10 (1):31-41.
  • Mastrorilli C, Spangler EA, Christopherson PW, Aubry OA, Smith AN, Kennis RA, Newton JC, Weismann JL, Moore PF. Multifocal cutaneous histiocytic sarcoma in a young dog and review of histiocytic cell immunophenotyping. Vet Clin Pathol 2012;41(3):412-418.
  • Koehler JW, Weiss RC, Aubry OA, Smith AN, Hathcock JT, Brawner WR. Nasal tumor with widespread cutaneous metastases in a golden retriever. Vet Pathol 2012;49:870-875.
  • O’Neill AM, Smith AN, Spangler EA, Whitley EM, Schleis SE, Bird RC, Curiel DT, Thacker EE, Smith BF. Resistance of canine lymphoma cells to adenoviral infection due to reduced cell surface RGD binding integrins. Cancer Biology & Therapy 2011;11(7): 651-658.
  • Crabtree AC, Beard DM, Smith AN, Spangler EA. Diagnostic accuracy of gray-scale ultrasonography for the detection of hepatic and splenic lymphoma in dogs. Vet Radiol & Ultrasound 2010;51(6):661-664.
  • Joiner KS, Smith AN, Henderson RA, Brawner WR, Spangler EA, Sartin EA. Multicentric cutaneous neuroendocrine (Merkel cell) carcinoma in a dog. Vet Pathol 2010;47(6):1090-1094.
  • Green N, Boothe DM, Smith A, Henderson R, Whitley EM. Ex vivo viability of canine and feline sarcomas: a pilot study. Vet Ther 2010;11(2):E1-11.
  • Bufkin BW, Beard DM, Henderson RA, Smith AN. What’s your diagnosis? Transitional cell carcinoma in the bladder of a dog. JAVMA 2009;235(12):1403-4.
  • Phillips B, Powers BE, Dernell WS, Straw RC, Khanna C, Hogge GS, Vail DM. Use of single-agent carboplatin as adjuvant or neoadjuvant therapy in conjunction with amputation for appendicular osteosarcoma. Am An Hosp Assoc 2009; 45: 33-38. (Case contributor)
  • Brugmann BL, Smith AN. Emergency management of chemotherapy patients with neutropenia and sepsis. Standards of Care: Emergency & Critical Care Medicine, 2008;10.8:1-6,11.
  • Gieger TL, Rassnick K, Siegel S, Proulx D, Bergman P, Anderson C, LaDue T, Smith A, Northrup N, Roberts R. Palliation of clinical signs in 48 dogs with nasal carcinomas treated with coarse-fraction radiation therapy. J Am An Hosp Assoc 2008;44:116-123.
  • Johannes CM, Henry CJ, Turnquist SE, Hamilton TA, Smith AN, Chun R, Tyler JW. Hemangiosarcoma in cats: 53 cases (1992-2002). J Am Vet Med Assoc 2007: 231: 1851-1856.
  • Smith AN. Practical matters: Ultrasonography’s limits in staging tumors. Veterinary Medicine 2007;102:164.
  • Taylor K, Smith AN, Higginbotham ML, Schwartz DD, Carpenter DM, Whitley EM. Expression of vascular endothelial growth factor (VEGF) in canine oral malignant melanoma. Vet Comparative Oncol 2007;5:208-218.
  • Smith AN. Practical matters:  Things to remember to calculate chemotherapy dosages correctly.  Veterinary Medicine pgs 101:638, 2006.
  • Bryan JN Henry CJ, Turnquist SE, Tyler JW, Rizzo SA, Sfiligoi G, Steinberg SJ, Smith AN, Jackson T. Primary renal neoplasia of dogs.  J Vet Intern Med 20:1155-1160, 2006.
  • Boozer AL, Behrend EN, Kemppainen RJ, Whitley EM, Smith AN, Busch KA. Hypothalamic-pituitary-adrenal axis function in dogs with neoplasia, Veterinary and Camparative Oncology pgs 194-202, 2005.
  • Smith AN. Hemangiosarcoma in dogs and cats.  Standards of Care: Emergency and critical care medicine 7.10:1-6, 2005.
  • Chun R, Garrett LD, Wall M, Smith A, Azene NM. Toxicity and efficacy of cisplatin and doxorubicin combination chemotherapy for the treatment of canine osteosarcoma. J Am An Hosp Assoc 41:382-387, 2005.
  • Behrend EN Kemppainen RJ, Boozer AL, Whitley EM, Smith, AN Busch KA.  Serum 17-alpha-hydroxyprogesterone and corticosterone concentrations in tumor-bearing dogs and dogs with suspected hyperadrenocorticism, J Am Vet Med Assoc 227:1762-1767, 2005.
  • Smith AN, Burke H, Heatley JJ, Beard D, Blue JT, Weiss RC.  Chemotherapy for lymphosarcoma in a mouse.  Exotic DVM 6.5, 2005.
  • Cohen M, Sartin EA, Whitley EM, Whitley RD, Brawner WR, Smith AN, Henderson RA, Behrend EN.  Ocular metastasis of a vaccine-associated fibrosarcoma in a cat.  J Comparative Oncol 1:232-240, 2003.
  • Axlund TW, McGlaason ML, Smith AN.  Treatment of intracranial meningiomas in the dog with surgery alone or in combination with irradiation (1989-2002).  J Am Vet Med Assoc 221:1597-1600, 2002.
  • Smith AN, Wright JC, Brawner WR, LaRue SM, Fineman L, Hoggenjaus AE, Burk RL, Dhalwal RS, Duda LE.  Radiation therapy in the treatment of canine and feline thymomas: a retrospective study (1985-99), J Am Anim Hosp Assoc 37:489-96, 2001.
  • Cohen M, Wright JC, BrawnerWR, Smith AN, Henderson RA, Behrend EN.  Use of surgery and electron beam radiation, with or without chemotherapy, for treatment of vaccine-associated sarcomas in cats: 78 cases (1996-2000),  J Am Vet Med Assoc 219:1582-89, 2001.
  • Smith AN, Spencer J, Stringfellow J, Vygantes K, Welch J.  Disseminated Phialemonium obovatum in a German shepherd dog.  J Am Vet Med Assoc 216:708-712, 2000.
  • Smith AN, Dillon AR, Finn-Bodner ST.  Left ventricular outflow tract to left atrial fistula associated with endocarditis in a dog.  J Am Anim Hosp Assoc 36:133-136, 2000.
  • Henry CJ, Turnquist SE, Smith A, Graham JC, Thamm DH, O'Brien M, Clifford CA.  Primary renal tumors in cats: 19 cases (1992-1998). J Feline Med & Surg pgs 165-170, 1999.
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