My research interest has always been focused on clinical use of injectable anesthetics and anesthetic managements in large animal species (e.g, horses, cattle, small ruminates, llamas, and sometimes exotic species).
The studies on comparison of different combinations of xylazine – ketamine, xylazine-ketamine-guaifenesin, xylazine-Telazol and detomidine-Telazol in horses allowed the practitioners to use these combinations of anesthetics in different surgery in the fields.
The use of DMSO in horses under inhalation anesthesia has eliminated the doubt of DMSO in increasing the risk of anesthesia when administered during surgery. The review article on anesthetic management in HYPP horses provides background information of the genetic disorder of HYPP horses and the particular anesthetic effects and anesthetic management on these horses.
My studies on xylazine–ketamine, xylazine-ketamine-guaifenesin, and xylazine-Telazol in sheep provide the information of the anesthetic effects allows practitioners to avoid potential complications they may face when anesthetizing these animals. Study using medetomidine and ketamine and its reversal with atipamezole in llamas provides options for using anesthetics other than xylazine and ketamine.
The result of clinical response and side effects of tolazoline, a xylazine reversal in calves, inform practitioners to be aware of the potential side effects of this drug and to ensure complete recovery of the animals from anesthesia and surgery. Long duration of analgesia produced by epidural administration of xylazine, detomidine, or medetomidine provides the practitioners choices other than lidocaine for perineal surgery and pain management.
Similarly, reports on anesthetic managements in zebras and ostriches are somewhat unique and provide useful information on “how to” safely anesthetize these unusual species. Results from the pharmacokinetic studies of epidural and local infiltration of lidocaine and ketamine offer important information concerning milk withdrawal time following administration of these two drugs to the food an7imal veterinarians and dairy producers.