Anne A. Wooldridge, DVM, MS, PhD, DACVIM

Dr. Anne Wooldridge received her Doctor of Veterinary Medicine degree from Texas A&M University in College Station, Texas in 1997. She completed specialty training in large animal internal medicine at Louisiana State University and obtained specialty board certification in 2001. During her residency at Louisiana State University, she completed a Master of Science degree in Veterinary Clinical Sciences. Her master’s thesis projects investigated the effects of various drugs on smooth and skeletal muscle contractile function in the equine esophagus. She then completed a Doctor of Philosophy degree in the Department of Pharmacology and Cancer Biology at Duke University in Durham, North Carolina in 2005. Her dissertation research focused on signaling pathways leading to calcium desensitization in smooth and skeletal muscle using a transgenic mouse model. She began a position as assistant professor in equine medicine at Auburn University in June 2007.


Research Interests

Linking metabolic alterations to abnormal vascular function in the horse.

My lab is interested in the connections between equine metabolic function and vascular function, particularly the effects of altered metabolic states on smooth muscle signaling pathways in equine laminar vessels. Obesity and inflammation-related insulin resistance are increasingly recognized in the horse. Insulin resistance is a major component of the pathogenesis of metabolic disease in horses, and it is increasingly recognized as a major component of the pathogenesis of sepsis. A growing body of evidence is linking systemic inflammation related to obesity with key molecules referred to as adipokines secreted from adipose tissue. Of these molecules, the adipokine adiponectin is of particular interest because it is a specific marker of metabolic disease in humans and directly controls insulin signaling.  Adiponectin increases insulin sensitivity and there is an emerging role of adiponectin as an anti-inflammatory signaling protein and as a modulator of endothelial function and blood flow.  I am collaborating with Dr. Robert Judd from the Department of Anatomy, Physiology, and Pharmacology to study adiponectin in the horse and to investigate links between adipokine signaling and altered vascular function that is part of the pathophysiology of diseases such as laminitis. 

Selected Publications

Wooldridge AA, Fortner CN, Lontay B, Akimoto T, Neppl RL, Facemire C, Datto MB, Kwon A, McCook E, Li P, Wang S, Thresher RJ, Miller SE, Perriard JC, Gavin TP, Hickner RC, Coffman TM, Somlyo AV, Yan Z, Haystead TA.  Deletion of the PKA/PKG target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle. J Biol Chem 283(17):11850-11859 (Apr 25), 2008.

Wooldridge AA, Haystead TA.  Real-time in vivo proteomic identification of novel kinase substrates in smooth muscle.  Methods Mol Biol 357:235-252, 2007.

Wooldridge AA, MacDonald JA, Erdodi F, Ma C, Borman MA, Hartshorne DJ, Haystead TA.  Smooth muscle phosphatase is regulated in vivo by exclusion of phosphorylation of threonine 696 of MYPT1 by phosphorylation of Serine 695 in response to cyclic nucleotides. J Biol Chem 279(33):34496-34504 (Aug 13), 2004.

Wooldridge AA, Eades SC, Hosgood GL, Moore RM.  Effects of treatment with oxytocin, xylazine butorphanol, guaifenesin, acepromazine, and detomidine on esophageal manometric pressure in conscious horses.  Am J Vet Res 63(12):1738-1744 (Dec), 2002.

Wooldridge AA, Eades SC, Hosgood GL, Moore RM.  In vitro effects of oxytocin, acepromazine, detomidine, xylazine, butorphanol, terbutaline, isoproterenol, and dantrolene on smooth and skeletal muscles of the equine esophagus.  Am J Vet Res 63(12):1732-1737 (Dec), 2002.

Wooldridge AA, Gill MS, Lemarchand T, Eilts B, Taylor HW, Otterson T.Gynecomastia and mammary gland adenocarcinoma in a Nubian buck.  Can Vet J 40(9):663-665 (Sept), 1999.

Wooldridge AA, Seahorn TL, Williams J, Taylor HW, Oliver JL, Kim DY, Vicek TJ.  Chronic renal failure associated with nephrolithiasis, ureterolithiasis, and renal dysplasia in a 2-year-old quarter horse gelding.  Vet Radiol Ultrasound 40(4):361-364 (Jul-Aug), 1999.

Martinez EA,Wooldridge AA, Hartsfield SM, Mealey KL.  Neuromuscular effects of doxacurium chloride in isoflurane-anesthetized dogs.  Vet Surg 27(3):279-283 (May-Jun), 1998.

Martinez E, Wooldridge A, Mercer D, Hartsfield S: Cardiovascular effects of doxacurium chloride in isoflurane‑anesthetized dogs. Veterinary Anaesthesia 24(1):10-14, 1997.

Martinez E, Wooldridge A, Hartsfield S: Effect of ketorolac tromethamine on atracurium­-induced neuromuscular blockade in anesthetized dogs. Vet Surg 26(6):510-514, 1997.

Martinez E, Mealey K, Wooldridge A, Mercer D, Cooper J,  Slater M,  Hartsfield S: Pharmacokinetics, effects on renal function, and potentiation of atracurium‑induced neuromuscular blockade after administration of a high dose of gentamicin in isoflurane-anesthetized dogs.  American Jourinal of Veterinary Research 57(11):1623-1626, 1996.

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