Dr. Blagburn’s research incorporates aspects of both basic and applied veterinary parasitology. Major efforts focus in two research areas: (1) protozoal diseases including Cryptosporidium spp., Neospora caninum, Toxoplasma gondii, Eimeria spp. Cystoisospora spp., Sarcocystis neurona, Hepatozoon spp. and Tritrichomonas spp. and (2) chemotherapeutic methods of parasite control. Within the discipline of chemotherapy, interests are broadened to include parasitic helminthes (heartworm and gastrointestinal species) and arthropods (particularly fleas, ticks and tick-borne diseases). Among tick borne diseases, the infectious agents of interest include Borrelia burgdorferi, Erhlichia spp, and Anaplasma spp.
Protozoal diseases: Major research initiatives involve, host/parasite interactions at the organismal, cellular and molecular levels, host immune responses, including methods of parasite immunomodulation of host responses and exploitation of host responses for diagnostic purposes, and potential methods of immunotherapeutic and chemotherapeutic control. Our laboratories have developed and currently maintain several in vivo and in vitro systems for development and maintenance of several protozoal organisms.
Developmental Chemotherapy: Research in this area involves the development of bovine, porcine, equine and canine and feline parasiticides. Efforts have focused on several classes of compounds including the benzimidazoles, probenzimidazoles, imidazothiazoles, polyether and macrolide parasiticides, thiamine analogues, benzoyl phenylureas, juvenile hormone analogs, as well as many insecticides/acaricides adult fleas and ticks. Other target parasites include gastrointestinal trichostrongylids in ruminants enteric and systemic coccidia of pigs, cattle, dogs and cats, and nematode and cestode parasites of cats and dogs.