Calvin M. Johnson, DVM, PhD, Dipl. ACVP

Before being named dean in 2013, Dr. Calvin Johnson served as department head and professor of pathology in the Department of Pathobiology, where he pursued research interests in infectious diseases, immunology and pathology.  He is a diplomate of the American College of Veterinary Pathologists, and serves as an anatomic pathologist in surgical and necropsy pathology.  Dr. Johnson instructs senior veterinary students in diagnostic pathology, participates in resident training, and mentors graduate students in experimental pathology.



Research Interests

Dr. Johnson’s laboratory investigates the pathogenesis of feline immunodeficiency virus (FIV) infection of domestic cats.   FIV is a lentivirus that resembles HIV in virion structure and virus-host interaction. Members of the laboratory investigate issues relevant to pediatric HIV infection, including the influence of fetal infection on the ontogeny of the immune system, the role of the thymus in pediatric AIDS pathogenesis, and the development of novel therapeutic strategies to enhance thymus function.  Clinical research interests include immunopathology, infectious diseases, and lymphoma.

Selected Publications

  • Dingman, P., Levy, J.K., Kramer, L.J., Johnson, C.M., Lappin, M.R., Greiner, E.C., Courtney, C.H., Tucker, S.J., Morchon, R. (2010) Association of Wolbachia with heartworm disease in cats and dogs, Veterinary Parasitology, 170 (1-2), 50-60
  • Koehler, J.W., Johnson, C.M., Beard, D., and Green, N (2010)  Pathology in Practice: Post-Traumatic Osteochondroma in a Dog.  J Am Vet Med Assoc, 237 (1), 45-7
  • Shaheen B.W., Wang C., Oyarzobel, O.,  Johnson C.M., Kaltenboeck B., Boothe D.M. (2010) Evaluation of the contribution of gyrA mutation and efflux pumps to fluoroquinolone and multidrug resistance in canine and feline pathogenic Escherichia coli isolates, Am J Vet Res, 72 (1), 25-32
  • Kuhnt L.A., Jennings R.N., Brawner W.R., Hathcock J.T., Carreno A.D., Johnson C.M. (2009) Magnetic resonance imaging of radiation-induced thymic atrophy as a model for pathologic changes in acute feline immunodeficiency virus infection. Journal of Feline Medicine and Surgery, 11 (12), 977-84
  • Bhaiyat, M.I., Hariharan, H, Chikweto, A., Brathwaite-Sylvester, E, Burnett, PJA, Matthew, V, Oliveira, C, and Johnson, C.M. (2009) Concurrent lymphosarcoma and Salmonella enteritidis infection in a cat: a case report. Veterinarni Medicina, 54 (9) 451-54
  • Pohlman, L.M., Higginbotham, M.L., Welles, E.G., and Johnson, C.M.  (2009) Immunophenotypic and Histologic Classification of 50 Cases of Feline Gastrointestinal Lymphoma.  Vet Pathol, 46: 259-268
  • Drake, D.A., Carreno, A.D., Blagburn, B.L., Little, S.E., West, M.D., Hendrix, C.M., and Johnson, C.M. (2008) Proliferative Sparganosis in a Dog.  J Am Vet Med Assoc, 233 (11) 1756-60
  • May, KA, Kuebelbeck, KL, and Johnson, C.M. (2008) Urinary Bladder Rupture Secondary to Penile and Preputial Squamous Cell Carcinoma in a Gelding.  Equine Veterinary Education, 20 (3) 135-139
  • Carreno, A.D., Mergia, A., Novak, J., Gengozian, N., and Johnson, C.M. (2008) Loss of Naive (CD45RA+) CD4+ Lymphocytes During Pediatric Infection with Feline Immunodeficiency Virus.  Veterinary Immunology and Immunopathology, 121: 161-168
  • Blagburn, B.L., Dillon, A.R., Tillson, D.M., Brawner, W.R., Welles, E., Johnson, C.M., Spencer, J.A., Kaltenboeck, B., Boothe, D.M., and Rynders, P. (2007) Feline Heartworm Disease: A New Perspective.  Insights in Veterinary Medicine,  5:3 1-5
  • Novak, J.M., Crawford, P.C., Kolenda-Roberts, H.M., Johnson, C.M., and Mergia, A.  (2007) Viral gene expression and provirus load of Orf-A defective FIV in lymphoid tissues and lymphocyte subpopulations of neonatal cats during acute and chronic infections.  Virus Research, 130 (1-2): 110-120
  • Kolenda-Roberts, HM, Kuhnt, LA, Jennings, RN, Mergia, A, Gengozian, N, and Johnson, C.M. (2007) Immunopathogenesis of feline immunodeficiency virus infection in the fetal and neonatal cat. Frontiers in Bioscience, 12: 3668-3682
  • Carreno, AD, Alleman, AR, Barbet, AF, Palmer, GH, Noh, SM, and Johnson, C.M. (2007)  In vivo endothelial cell infection by Anaplasma marginale, Veterinary Pathology, 44: 116-118
  • Sweat, JM, Johnson, C.M., Marikar, Y., Gibbs, EP (2005) Characterization of surface Interleukin-2 receptor expression on gated populations of peripheral blood mononuclear cells from manatees, Trichechus manatus latirostris, Veterinary Immunology and Immunopathology, 108: 269-283
  • Park, J, Nadeau, P, Zucali, JR, Johnson, C.M., Mergia, A (2005) Inhibition of simian immunodeficiency virus by foamy virus vectors expressing siRNAs, Virology, 343: 275-282
  • Crawford PC, Dubovi EJ, Castleman WL, Stephenson I, Gibbs EP, Chen L, Smith C, Hill RC, Ferro P, Pompey J, Bright RA, Medina MJ, Johnson C.M., Olsen CW, Cox NJ, Klimov AI, Katz JM, Donis RO (2005) Transmission of equine influenza virus to dogs., Science, 310 (5747): 482-485
  • Brown, L, Carter, TD, Snyder, P, Levy, JK, Johnson, C.M. (2005) Pulmonary Arterial Disease in Cats Seropositive for Dirofilaria Immitis But Lacking Cardiopulmonary Adult Heartworms, American Journal of Veterinary Research, 66(9): 1544-1549
  • Wellehan JF, Johnson AJ, Harrach B, Benko M, Pessier AP, Johnson C.M., Garner MM, Childress A, Jacobson ER (2004) Detection and analysis of six lizard adenoviruses by consensus primer PCR provides further evidence of a reptilian origin for the atadenoviruses, Journal of Virology, 78(23): 13366-13369
  • Johnson C.M., Gengozian N, Mergia A (2004) Hematopoiesis in the feline fetal liver: an assessment by flow cytometry, Veterinary Immunology and Immunopathology, 99(1-2): 53-62
  • Cook AL (2004) Beta 2 microglobulin and resistance to murine respiratory mycoplasmosis [Corrected citation 43 (4): 7], Contemporary Topics in Laboratory Animal Science / American Association for Laboratory Animal Science, 43(3): 18-24
  • Jacobson, ER, Robertson, DR, Lafortune, M, and Johnson, C.M. (2004) Renal Failure and Bilateral Thymoma in an American Bullfrog, Rana catesbiana, J Herpe Med Surg, 14(2): 15-20
  • Fleming, GJ, Heard DJ, Uhl, EW, Johnson, C.M. (2004) Thymic Hyperplasia in Sub-adult Galapagos Tortoises (Geochelone nigra), J Herpe Med Surg, 14(1): 24-27
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