Dr. Kaltenboeck’s research is directed towards creating vaccines against chlamydial infections and diseases caused by intracellular bacteria of the genus Chlamydia. The primary goal is to create such vaccines against ubiquitous herd infections with C. abortus and C. pecorum in livestock, and against human infection by C. pneumoniae. The approach towards this goal builds 1) on a sophisticated understanding created in epidemiological research on the transmission and impact of these infections in cattle. This research relies strongly on high-sensitivity real-time PCR and ELISA methodology developed in Dr. Kaltenboeck’s laboratory. Another key element in chlamydial vaccine development and future application is 2) an improved understanding of the pathogenesis of chlamydial infections as acquired in a mouse model of chlamydial lung disease. The application of 3) real-time PCR methodology for detection and quantification of chlamydial DNA as well as host mRNA and the murine chlamydial lung disease model have lead to the identification of chlamydial vaccine candidate genes in systematic screens of chlamydial genomes by expression library immunization. Dr. Kaltenboeck’s research has been funded by grants from the National Institutes of Health, US Department of Agriculture, Diabetes Trust and Diabetes Action Research & Education Foundations, Auburn University College of Veterinary Medicine, Alabama Agricultural Experiment Station Foundation, as well as several pharmaceutical and biotecholgy companies.