Joseph C. Newton, DVM, PhD

Dr. Joseph C. Newton, associate professor of pathology, received his DVM degree in 1978 and his Ph.D. degree in veterinary pathology in 1987 from Auburn University. He served on the faculty of Louisiana State University School of Veterinary Medicine from 1987 to 1993. In 1993, Dr. Newton joined the faculty in the Department of Pathobiology, Auburn University as pathologist for aquatic animal species. Dr. Newton is active in departmental teaching and service programs.


Research Interests

My major research interests center on infectious diseases of farm-raised channel catfish, in particular, enteric septicemia of catfish caused by Edwardsiella ictaluri and columnaris disease caused by Flavobacterium columnare.  We have studied the pathogenesis of enteric septicemia and have isolated and characterized various components of the outer membrane of the bacterium. Knowledge of the outer membrane proteins, lipopolysaccharide, flagella, etc. of E. ictaluri will allow us to define the virulence mechanisms of the organism. We have also carried out experiments to identify and characterize the antigens of E. ictaluri that are immunogenic to catfish. These antigens might prove useful as immunogens in subunit vaccines to protect catfish from infection by E. ictaluri.    Characterization of the metalloprotease(s) of Flavobacterium columnare is also an ongoing research interest.  Columnaris disease is an important disease in most food fish raised in freshwater and in freshwater aquarium fish.  The metalloprotease(s) are believed to play important roles in the pathogenesis of columnaris disease.

We are also working with Pythium insidiosum, an oomycete that causes equine and canine pythiosis. We have developed an ELISA test that is useful in diagnosing the disease in dogs and horses and have also worked to develop immunotherapeutic agents for equine pythiosis.

Selected Publications

Brunson, B.L., Taintor, J., Newton, J., Schumacher, J., Christmann, U. 2006. Vascular hamartoma in the tongue of a horse. Journal of Equine Veterinary Science 26:6, 275-277.

MendozaL and J Newton. 2005.  Immunology and immunotherapy of the infections caused by Pythium insidiosum. Medical Mycology 43:6: 477-486.

Darwish A., Ismaiel A., Newton J., and Tang J.  2004. Molecular identification of Flavobacterium columnare by species-specific polymerase chain reaction primers to the 16 S ribosomal RNA gene.  Molecular and Cellular Probes, accepted for publication.

Darwish A, J Plumb and J Newton. 2001.  Effect of Incubation Temperature and Different Salinities on Expression of Outer Membrane Protein Profiles of Edwardsiella tarda.  Journal of Aquatic Animal Health 13:3. 269-275.

Darwish A, J Plumb and J Newton. 2000.  Histopathology and Pathogenesis of Experimental Infection with Edwardsiella tarda in Channel Catfish.  Journal of Aquatic Animal Health 12:4. 255-266.

Newton, JC, Wood TM and Hartley MM.  1997.  Isolation and partial characterization of extracelluar proteases produced by isolates of Flavobacterium columnare derived from channel catfish.  J Aquatic Animal Health 9:2. p 75-85.

Baldwin TJ, Collins LA and Newton JC.  1997.  Antigens of Edwardsiella ictaluri recognized by serum antibodies from naturally infected channel catfish.  Fish and Shellfish Immunology 7:3.  p 261-271.

Newton JC and Triche PT. 1993.  Electrophoretic and immunochemical characterization of lipopolysaccharide of Edwardsiella ictaluri from channel catfish.  J Aquatic Animal Health 5. p 246-253.

Baldwin TJ and Newton JC. 1993.  Early events in the pathogenesis of enteric septicemia of catfish, caused by Edwardsiella ictaluri:  Microscopic and bacteriologic findings.  J Aquatic Animal Health 5. p 189-198.

Newton JC and Triche PT.  1993.  Isolation and characterization of the flagella of Edwardsiella ictaluri. J Aquatic Animal Health 5. p 16-22.

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