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Dr. Valery A. Petrenko, Professor

334-844-2897
petreva@auburn.edu

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Valery A. Petrenko, Professor in the Department of Pathobiology at Auburn University, graduated fromMoscow State University, Russia (1972). He received the PhD and D.Sc. degrees in chemistry from the Zelinski Institute of Organic Chemistry, Moscow, U.S.S.R. (1976) and Moscow State University (1988), and Honor Ranks of Senior Scientist in Bioorganic Chemistry (1984) and Professor in Molecular Biology (1992) from the Supreme Attestation Committee of the Government of the U.S.S.R. His Ph.D. research focused on the synthesis of O-specific antigens of Salmonella, and D.Sc.—on directed engineering of DNA and proteins.  In 1977 he moved to Novosibirsk and worked as Junior and Senior Scientist (1977-1982), Laboratory Head (1982-1985), Scientific Deputy Director (1985-1989), Director of Institute, Scientific Deputy General Director and Professor (1989-1993) in Scientific Association “Vector” (Novosibirsk, Russia).  In 1993 he joined the faculty of University of Missouri-Columbia as Visiting Professor and Research Professor, and in 2000—the faculty of Auburn University as Professor. He was appointed to the Graduate Faculty in 2001. In Auburn Dr. Petrenko established a research program focused on development of diagnostic and therapeutic probes using directed evolution of phage. Dr. Petrenko is recipient (PI) of grants from the Army Research Office and the National Institute of Health, Calvert Research LLC, recipient of the Pfizer Animal Health Award for Research Excellence (2006) and CoPI in several collaborative grants. He is member of American Association of Pharmaceutical Scientists and Phi Zeta Honor Society of Veterinary Medicine.

Research Interests

  • Monitoring and detection of biological threats 
  • Targeted drug/gene delivery
  • Diagnosis of infectious diseases and cancer

To attack these problems, Professor Petrenko employs methods of phage nanobiotechnology that are being developed by his group. This program is a logical continuation of his previous study of landscape phage libraries. 

Selected Publications

  1.  2010  Abbineni, Gopal; Modali, Sita; Safiejko-Mroczka, Barbara; Petrenko, Valery; Mao, Chuanbin. "Evolutionary selection of new breast cancer cell-targeting peptides and phages with the cell-targeting peptides fully displayed on the major coat and their effects on actin dynamics during cell internalization". Molecular Pharmaceutics (In Press).

  2. Wang T, Petrenko VA, Torchilin VP. Paclitaxel-Loaded Polymeric Micelles Modified with MCF-7 Cell-Specific Phage Protein: Enhanced Binding to Target Cancer Cells and Increased Cytotoxicity.Mol Pharm. 2010 Jun 10. [Epub ahead of print]PMID: 20518562

  3. Wang T, D'Souza GG, Bedi D, Fagbohun OA, Potturi LP, Papahadjopoulos-Sternberg B, Petrenko VA, Torchilin VP. Enhanced binding and killing of target tumor cells by drug-loaded liposomes modified with tumor-specific phage fusion coat protein.  Nanomedicine (Lond). 2010 Jun;5(4):563-74.PMID: 20528452

  4. Wang T, Yang S, Petrenko VA, Torchilin VP. Cytoplasmic Delivery of Liposomes into MCF-7 Breast Cancer Cells Mediated by Cell-Specific Phage Fusion Coat Protein. Mol Pharm. 2010 Jun 14. [Epub ahead of print]PMID: 20438086

  5. Jayanna PK, Bedi D, Deinnocentes P, Bird RC, Petrenko VA. Landscape phage ligands for PC3 prostate carcinoma cells. Protein Eng Des Sel. 2010 Feb 25. [Epub ahead of print]PMID: 20185523 [PubMed - as supplied by publisher]Related articles

  6.  Jayanna PK, Bedi D, Gillespie JW, Deinnocentes P, Wang T, Torchilin VP, Bird RC, Petrenko VA.Landscape phage fusion protein-mediated targeting of nanomedicines enhances their prostate tumor cell association and cytotoxic efficiency.  Nanomedicine. 2010 Feb 4. [Epub ahead of print]

  7. Shen, W; Mathison, LC; Petrenko, VA; Chin, BA. Design and characterization of a magnetoelastic sensor for the detection of biological agents. JOURNAL OF PHYSICS D-APPLIED PHYSICS 43 (1): Art. No. 015004 JAN 13 2010.

  8. 2009  G.A. Kuzmicheva, P.K. Jayanna, A.M. Eroshkin, M.A. Grishina, E.S. Pereyaslavskaya, V.A. Potemkin, and V.A. Petrenko (2009) Mutations in fd phage major coat protein modulate affinity of the displayed peptide. Protein Engineering, Design and Selection 2009 22: 631-639. PEDS Advance Access published on July 25, 2009.

  9. Jayanna P.K., Torchilin V.P. and V.A. Petrenko (2009) Liposomes targeted by fusion phage proteins. Nanomedicine,  2009 Mar;5(1):83-9. Epub 2008 Oct 1.

  10. Shen, W; Lakshmanan, RS; Mathison, LC; Petrenko, VA; Chin, BA. Phage coated magnetoelastic micro-biosensors for real-time detection of Bacillus anthracis spores. Sensors and Actuators B-Chemical 137 (2): 501-506 APR 2 2009.

  11. S. Huang, H. Yang, R.S. Lakshmanan, M.L. Johnson, J. Wan, I.-H. Chen, H.C. Wikle III, V.A. Petrenko, J.M. Barbaree, B.A. Chin. Sequential detection of Salmonella typhimurium and Bacillus anthracis sporesusing magnetoelastic biosensors. Biosensors and Bioelectronics. 24 (6), p.1730-1736, Feb 2009.

  12. G.A. Kuzmicheva, P.K. Jayanna, I.B. Sorokulova and V.A. Petrenko (2009) Diversity and censoring of landscape phage libraries. Protein Engineering, Design, and Selection. 2009 Jan;22(1):9-18. Epub 2008 Nov 6.

  13. 2008  S. Huang, S.-Q. Li, H. Yang, M. Johnson, J. Wan, I. Chen, V. A. Petrenko, J. M. Barbaree, and B. A. Chin. Optimization of Phage-Based Magnetoelastic Biosensor Performance. Sensors & Transducers Journal, Vol. 3, Special Issue, December 2008, pp.87-96.  Available online:http://www.sensorsportal.com/HTML/DIGEST/P_SI_59.htm

  14. Petrenko V.A.  (2008) Evolution of Phage Display: From Bioactive Peptides to Bioselective Nanomaterials. Expert Opinion on Drug Delivery (EODD), Aug;5(8):825-36.

  15. S. Huang, H. Yang, R.S. Lakshmanan, M.L. Johnson, I. Chen, J. Wan, H.C. Wikle, V.A. Petrenko, J.M. Barbaree, Z.Y. Cheng, B.A. Chin (2008). The Effect of Salt and Phage Concentrations on the Binding Sensitivity of Magnetoelastic Biosensors for Bacillus anthracis Detection. Biotechnology and Bioengineering, 101 (5): 1014-1021 DEC 1 2008.

  16. Johnson M.L., Wan J., Huang S., Cheng Z., Petrenko V.A. Kim D.-J., Chen I.-H., Barbaree J.M.,  Hong J.W., and B.A. Chin (2008). A Wireless Biosensor Using Microfabricated Phage-Interfaced Magnetoelastic Particles. Sensors & Actuators A: Physical. Vol 144/1 pp 38-47.

  17. Brigati, J.R., Samoylova, T.I., Jayanna, P.K. and V.A. Petrenko (2008) Phage display technique for generating peptide reagents. In: Current Protocols in Protein Science (Editor Ben M. Dunn, et al.). John Wiley & Sons.

  18. Petrenko V.A.  (2008). Landscape phage as a molecular recognition interface for detection devices.  Review. Microelectronics Journal,  Vol 39/2 pp 202-207. 

  19. Suiqiong Li, Michael Johnson, Jiehui Wan, Valery Petrenko, and Bryan Chin. “Microfabricated Magnetoelastic Biosensors for the Detection of Bacillus Anthracis Spores.” ECS Transactions (Issue Title: Chemical Sensors 8: Chemical (Gas, Ion, Bio) Sensors and Analytical Systems), Vol. 16, pp 177-185, 2008. doi:10.1149/1.2981119

  20. 2007  Fu. L., Li, S., Zhang, K., Chen, I-H., Petrenko, V.A.  and Z.-Y. Cheng, (2007), Magnetostrictive microcantilever as an advanced transducer for biosensors, Sensors Journal, V.7, 2929-2941.

  21. Lakshmanan, RS; Guntupalli, R; Hu, J; Petrenko, VA; Barbaree, JM; Chin, BA. Detection ofSalmonella typhimurium in fat free milk using a phage immobilized magnetoelastic sensor. Sensors and actuators B-Chemical 126 (2): 544-550 OCT 1 2007

  22. Lakshmanan RS, Guntupalli R, Hu J, Kim DJ, Petrenko VA, Barbaree JM, Chin BA (2007). Phage based magnetoelastic sensor for the detection of Salmonella typhimurium. Microbiol Methods. Oct;71(1):55-60. Epub 2007 Aug 9.

  23. Valery A. Petrenko (2007) Phage-Derived Bioselective Nanovehicles For Drug And Gene Delivery. Nanotech 2007, V. 2. p.703-706, Technical Proceedings, CRC Press, Taylor & Francis Group.

  24. Wan, J., Johnson, M.,  Guntupalli,R.,  Petrenko,V.A. and B.A. Chin (2007), "Detection of Bacillus anthracis spores in liquid using phage-based magnetoelastic micro-resonators", Sensors and actuators B, 127: 559-566.

  25. Wan, J., Shu, H., Huang, S., Fiebor, B., Chen, I-H., Petrenko, V.A., Chin, B.A. (2007), Phage-based Magnetoelastic wireless biosensors for detecting Bacillus anthracis spores. IEEE Sensor Journal, vol 7 No. 3 pp 470-477.

  26. Petrenko V.A. &  J.R. Brigati (2007) Phage As Biospecific Probes. In: Immunoassay and other Bioanalytical Techniques (Editor Jeanette M. Van Emon). CRC Press, Taylor & Francis Group, Boca Raton, FL, U.S.A..

  27. Nanduri V., Sorokulova I.B., Samoylov A.M., Simonian A.L., Petrenko V.A., and V.J. Vodyanoy (2007).  Phage as molecular recognition elements in biosensors immobilized by physical adsorption. Biosensors and Bioelectronics. 22(6):986-92..

  28. E.Olsen, J. Sykora, I. Sorokulova, W. Neely, I. Chen, J. Barbaree V. Petrenko and V. Vodyanoy(2007). Phage Fusion Proteins as Bioselective Receptors for Piezoelectric Sensors. ECS Transactions, 2(19), 9-25.  

  29. 2006  Olsen E.V., Sorokulova I.B., Petrenko V.A., Chen I-H., Barbaree J.M., and V.J. Vodyanoy(2006).  Affinity-selected filamentous bacteriophage as a probe for acoustic wave biodetectors ofSalmonella typhimurium.  Biosensors and Bioelectronics. V21: p.1434-1442.

  30. 2005  Petrenko V.A. & G.P. Smith (2005) Vectors and Modes of Display. In: Phage Display in Biotechnology and Drug Discovery (Editor S. Sidhu). CRC Press, Taylor & Francis Group, Boca Raton, FL, U.S.A., 714pp.

  31. Brigati J.R. and V.A. Petrenko (2005).  Thermostability of Landscape Phage Probes.  Analytical and Bioanalytical Chemistry. V.382, p.1346-1350.

  32. Sorokulova I.B., E.V. Olsen, I-H. Chen, B. Fiebor, J.M. Barbaree, V.J. Vodyanoy, B.A. Chin and V.A. Petrenko (2005).  Landscape Phage Probes for Salmonella typhimurium.   The Journal of Microbiological Methods. V. 63, No 1, p. 55-72..

  33. 2004  Mount J., T.I. Samoylova, N.E. Morrison, N.R. Cox, H.J. Baker and V.A. Petrenko. (2004) Cell Targeted Phagemid Recurred by Pre-Selected Landscape Phage. Gene. V.341, p.59-65.

  34. Brigati J., D.D. Williams, I.B. Sorokulova, V. Nanduri, I-H. Chen, C.L. Turnbough, Jr. and V.A. Petrenko (2004).  Diagnostic probes for Bacillus anthracis spores selected from a landscape phage library.  Clinical Chemistry. V.50, No.11, p.1899-1906.

  35. Samoylova T.I. , N.R. Cox, N.E. Morrison, L.P. Globa, V. Romanov, H.J. Baker, and V.A. Petrenko (2004).  Phage matrix for isolation of glioma cell-membrane proteins.  BioTechniques, V.37, No. 2, p.254-260

  36. Petrenko V.A. and I.B. Sorokulova (2004) Detection of Biological Threat Agents. A challenge for Combinatorial Biochemistry. The Journal of Microbiological Methods Vol 58/2 pp 147-168.

  37. 2003  Samoylova T.I., V.A. Petrenko, N.E. Morrison, L.P. Globa, H.J. Baker, and N.R. Cox (2003). Phage Probes for Malignant Glial Cells.  Molecular Cancer Therapeutic.   V.2, p.1129-1137.

  38. Petrenko V.A. and V.J. Vodyanoy (2003) Phage display for detection of biological threat agents. The Journal of Microbiological Methods, 53/2 pp. 243-252. 

  39. 2002  Petrenko V.A., Smith G.P., Mazooji M.M. and Quinn T.  (2002) Alfa-helically constrained phage display library.  Protein Engineering, V.15, No.11, pp.943-950. 

  40. 2001  Romanov V.I., Durand D.E. and Petrenko V.A. (2001) Phage Display Selection On Prostate Carcinoma Cells Yields A Peptide Affecting Cells Spreading And Invasion.  The Prostate, V.47, p.239-251. 

  41. Kouzmitcheva G.A., Petrenko V.A. and Smith G.P. (2001) Diagnostic Peptides for Lyme Disease Through Epitope Discovery. Clinical and  Diagnostic Laboratory Immunology, V8, p.150-160.

  42. 2000  Petrenko V.A. and Smith G.P. (2000) Phage from landscape libraries as substitute antibodies.   Protein Engineering, V.13, N8, p.101-104.

  43. 1989-1998   Smith G.P., V.A. Petrenko and L.L. Metthews (1998) Cross-Linked Filamentous Phage as an Affinity Matrix. Journal of Immunological Methods, V.215, p.151-161.

  44. Smith G.P. and Petrenko V.A. (1997) Phage Display. Chemical Reviews, V.97, N2, p. 391-410. 

  45. Petrenko, V.A. (1997) A library of organic landscapes on filamentous phage. In Paul Guttry (Editor), Display Technologies. Novel Targets and Strategies. IBC Library Series, pp.51-70.

  46. Petrenko V.A., Smith G.P., Gong X. and Quinn T. (1996) A library of organic landscapes on filamentous phage. Protein Engineering, V.9, N9, p. 797-801.

  47. Minenkova O.O., A.A. Ilyichev, G.P. Kishchenko and V.A. Petrenko (1993) Design  of  specific  immunogen  using  filamentous phages as a carrier. Gene, 128, 85-88.

  48. Kishchenko G.P., O.O. Minenkova, A.A. Ilyichev, A.D. Gruzdev, V.A. Petrenko (1991) Study of the structure of phage-M13 virions containing chimeric B-protein molecules. Molekulyarnaya biologiya, 25, 1497-1503. Molecular Biology, 1991, 25(6), 1171-1176.

  49. Ilyichev A.A., O.O. Minenkova, S.I. Tatkov, N.N. Karpyshev, A.M. Eroshkin, V.I. Ofitserov, Z.A. Akimenko, V.A. Petrenko, L.S. Sandakhchiev (1990) M13 filamentous bacteriophage in protein engineering. Molekulyarnaya biologiya., 24, 530-535. Molecular Biology.-Engl. Tr., 1990, 24(2), 435-440.

  50. Ilyichev A.A., O.O. Minenkova, S.I. Tatkov, N.N. Karpyshev, A.M. Eroshkin, V.A. Petrenko,  L.S.  Sandakhchiev (1989) Production of a viable variant of phage M13 with incorporated foreign peptide in the major coat protein. Doklady Akademii nauk SSSR., 307, 481-483. Doklady Biochemistry (Proc. Acad.  Sci.  USSR)-Engl.Tr., 1989, 307, 196-198.  

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