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Dr. Valery A. Petrenko, Professor

Valery A. Petrenko, Professor in the Department of Pathobiology at Auburn University, graduated from Moscow State University, Russia (1972). He received the PhD and D.Sc. degrees in chemistry from the Zelinski Institute of Organic Chemistry, Moscow, Russia (1976) and Moscow State University (1988), and Honor Rank of Professor in Molecular Biology from Supreme Attestation Committee of Russia (1992). His Ph.D. research focused on the synthesis of O-specific antigens of Salmonella, and D.Sc.—on directed engineering of DNA and proteins.  In 1977 he moved to Novosibirsk and worked as Junior and Senior Scientist (1977-1982), Laboratory Head (1982-1985), Scientific Deputy Director (1985-1989), Director of Institute, Scientific Deputy General Director and Professor (1989-1993) in Scientific Association “Vector” (Novosibirsk, Russia).  In 1993 he joined the faculty of University of Missouri-Columbia as Visiting Professor and Research Professor, and in 2000—the faculty of Auburn University as Professor. He was appointed to the Graduate Faculty in 2001. In Auburn Dr. Petrenko established a research program focused on development of diagnostic and therapeutic probes using directed evolution of phage. Dr. Petrenko is recipient (PI) of grants from the Army Research Office and the National Institute of Health, recipient of the Pfizer Animal Health Award for Research Excellence (2006) and CoPI in several collaborative grants. He is member of American Chemical Society.

334-844-2897
petreva@auburn.edu

Research Interests

Monitoring and detection of biological threats 
Targeted drug delivery
Diagnosis of infectious diseases and cancer

Selected Publications

Petrenko V.A. &  J.R. Brigati (2007) Phage As Biospecific Probes. In: Immunoassay and other Bioanalytical Techniques (Editor Jeanette M. Van Emon). CRC Press, Taylor & Francis Group, Boca Raton, FL, U.S.A..

Wan, J., Shu, H., Huang, S., Fiebor, B., Chen, I-H., Petrenko, V.A., Chin, B.A. (2007), Phage-based Magnetoelastic wireless biosensors for detecting Bacillus anthracis spores. IEEE Sensor Journal, vol 7 No. 3 pp 470-477.

Nanduri V., Sorokulova I.B., Samoylov A.M., Simonian A.L., Petrenko V.A., and V.J. Vodyanoy (2007). Phage as molecular recognition elements in biosensors immobilized by physical adsorption. Biosensors and Bioelectronics. 22(6):986-92..

E.Olsen, J. Sykora, I. Sorokulova, W. Neely, I. Chen, J. Barbaree Petrenko, V. A., and V. Vodyanoy (2007). Phage Fusion Proteins as Bioselective Receptors for Piezoelectric Sensors. ECS Transactions, 2(19), 9-25.  

Olsen E.V., Sorokulova I.B., Petrenko V.A., Chen I-H., Barbaree J.M., and V.J. Vodyanoy (2006).  Affinity-selected filamentous bacteriophage as a probe for acoustic wave biodetectors of Salmonella typhimurium.  Biosensors and Bioelectronics. V21: p.1434-1442.

Petrenko V.A. & G.P. Smith (2005) Vectors and Modes of Display. In: Phage Display in Biotechnology and Drug Discovery (Editor S. Sidhu). CRC Press, Taylor & Francis Group, Boca Raton, FL, U.S.A., 714pp.

Brigati J.R. and V.A. Petrenko (2005).  Thermostability of Landscape Phage Probes.  Analytical and Bioanalytical Chemistry. V.382, p.1346-1350.

Sorokulova I.B., E.V. Olsen, I-H. Chen, B. Fiebor, J.M. Barbaree, V.J. Vodyanoy, B.A. Chin and V.A. Petrenko (2005).  Landscape Phage Probes for Salmonella typhimurium.   The Journal of Microbiological Methods. V. 63, No 1, p. 55-72..

Mount J., T.I. Samoylova, N.E. Morrison, N.R. Cox, H.J. Baker and V.A. Petrenko. (2004) Cell Targeted Phagemid Recurred by Pre-Selected Landscape Phage. Gene. V.341, p.59-65.

Brigati J., D.D. Williams, I.B. Sorokulova, V. Nanduri, I-H. Chen, C.L. Turnbough, Jr. and V.A. Petrenko (2004).  Diagnostic probes for Bacillus anthracis spores selected from a landscape phage library.  Clinical Chemistry. V.50, No.11, p.1899-1906.

Samoylova T.I. , N.R. Cox, N.E. Morrison, L.P. Globa, V. Romanov, H.J. Baker, and V.A. Petrenko (2004).  Phage matrix for isolation of glioma cell-membrane proteins.  BioTechniques, V.37, No. 2, p.254-260

Petrenko V.A. and I.B. Sorokulova (2004) Detection of Biological Threat Agents. A challenge for Combinatorial Biochemistry. The Journal of Microbiological Methods Vol 58/2 pp 147-168.

Samoylova T.I., V.A. Petrenko, N.E. Morrison, L.P. Globa, H.J. Baker, and N.R. Cox (2003). Phage Probes for Malignant Glial Cells.  Molecular Cancer Therapeutic.   V.2, p.1129-1137.

Petrenko V.A. and V.J. Vodyanoy (2003) Phage display for detection of biological threat agents.  The Journal of Microbiological Methods, 53/2 pp. 243-252. 

Petrenko V.A., Smith G.P., Mazooji M.M. and Quinn T.  (2002) Alfa-helically constrained phage display library.  Protein Engineering, V.15, No.11, pp.943-950. 

RomanovV.I., Durand D.E. and Petrenko V.A. (2001) Phage Display Selection On Prostate Carcinoma Cells Yields A Peptide Affecting Cells Spreading And Invasion.  The Prostate, V.47, p.239-251. 

Kouzmitcheva G.A., Petrenko V.A. and Smith G.P. (2001) Diagnostic Peptides for Lyme Disease Through Epitope Discovery. Clinical and  Diagnostic Laboratory Immunology, V8, p.150-160.

Petrenko V.A. and Smith G.P. (2000) Phage from landscape libraries as substitute antibodies.   Protein Engineering, V.13, N8, p.101-104.

Smith G.P., V.A. Petrenko and L.L. Metthews (1998) Cross-Linked Filamentous Phage as an Affinity Matrix. Journal of Immunological Methods, V.215, p.151-161.

Smith G.P. and Petrenko V.A. (1997) Phage Display. Chemical Reviews, V.97, N2, p. 391-410. 

Petrenko, V.A. (1997) A library of organic landscapes on filamentous phage. In Paul Guttry (Editor), Display Technologies. Novel Targets and Strategies. IBC Library Series, pp.51-70.

Petrenko V.A., Smith G.P., Gong X. and Quinn T. (1996) A library of organic landscapes on filamentous phage. Protein Engineering, V.9, N9, p. 797-801.

Minenkova O.O., A.A. Ilyichev, G.P. Kishchenko and V.A. Petrenko (1993) Design  of  specific  immunogen  using  filamentous phages as a carrier. Gene, 128, 85-88.

Kishchenko G.P., O.O. Minenkova, A.A. Ilyichev, A.D. Gruzdev, V.A. Petrenko (1991) Study of the structure of phage-M13 virions containing chimeric B-protein molecules. Molekulyarnaya biologiya, 25, 1497-1503. Molecular Biology, 1991, 25(6), 1171-1176.

Ilyichev A.A., O.O. Minenkova, S.I. Tatkov, N.N. Karpyshev, A.M. Eroshkin, V.A. Petrenko,  L.S.  Sandakhchiev (1989) Production of a viable variant of phage M13 with incorporated foreign peptide in the major coat protein. Doklady Akademii nauk SSSR., 307, 481-483. Doklady Biochemistry (Proc. Acad.  Sci.  USSR)-Engl.Tr., 1989, 307, 196-198.  

Additional Links

  • Dr. Valery Petrenko (Personal Web Page)