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Frederik W. van Ginkel, PhD

Dr. Frederik W. van Ginkel is an Associate Professor in the Department of Pathobiology.  He earned his B.Sc. degree in Biology in 1981 and his M.Sc. in Cellular Biology in 1984 at the Agricultural University in Wageningen, the Netherlands. He obtained a Ph.D. in Microbiolgy at the University of Mississippi Medical Center in 1993 after which he pursued a postdoctoral fellowship at the University of Alabama at Birmingham and joined the faculty there in 2000 as a Research Assistant Professor.  He moved to Auburn in 2004 where his research is focused on mucosal immunology and he is active in the training of graduate and professional students.
334-844-0132
vangifw@auburn.edu

Research Interests

My research in the last few years has focused on mucosal immune responses in the respiratory tract to bacterial and viral pathogens and viral vectors.  This model measures mucosal immunity in chickens following immunization for avian influenza virus or following exposure to other respiratory chicken viruses.  These studies have focused on the Harderian glands and conjunctiva-associated lymphoid tissue as mucosal effector sites and are analyzing their role in protection against avian pathogens.   

Selected Publications

van Ginkel, F.W., C-J. Liu, J.W. Simecka, J-Y. Dong, T. Greenway, R.A. Frizzell, H. Kiyono, J.R. McGhee, and  D.W. Pascual. 1995.  Intratracheal gene delivery with adenoviral vector induces elevated systemic IgG and mucosal IgA antibodies to adenovirus and B-galactosidase.  Human Gene Therapy 6 : 895-903.

van  Ginkel, F.W., and D.W. Pascual. 1996  Recognition of neurokinin 1 receptor (NK1-R): an antibody to a peptide sequence from the third extracellular region binds to brain NK1-R . J. Neuroimmunol.  67: 49-58.

van Ginkel, F.W.,H. Kiyono and J.R. McGhee. 1997.  Human  papillomavirus and mucosal immunity in the female reproductive tract. Papillomavirus  Report 8 : 1-10.

van Ginkel. F.W., J.R. McGhee, C-J. Liu, J.L. Simecka, R.A. Frizzell, E.J. Sorscher, H. Kiyono, and D.W. Pascual.  1997.  Segregation of CD4 T helper cell responses to Ad5 vector and transgene.  J. Immunol. 159: 685-693.

Yamamoto, S., H. Kiyono, M. Yamamoto, I. Imaoka, M. Yamamoto, K. Fujihashi, Y. Takeda, F.W. van Ginkel, and J.R. McGhee. 1997.  A nontoxic mutant of cholera toxin enhances mucosal immunity.  Proc. Natl. Acad. Sci. USA.  94: 5267-5272.

van Ginkel, F.W.,Jackson, R.J., Yuki, Y., and McGhee, J.R.. 2000. The mucosal adjuvant cholera toxin redirects vaccine proteins into   olfactory tissues.  J. Immunol. Cutting Edge 165: 4778-4782.

Nguyen, H.H, F.W. van Ginkel, H.L. Vu, M.J. Novak, H. Kiyono, J.R.    McGhee, and J. Mestecky. 2000. Gamma interferon is not required for mucosal cytotoxic T lymphocyte responses of heterosubtypic immunity to influenza A virus infection in mice.  J. Virol. 74: 5495-5501.

Nguyen, H.H., F.W. van Ginkel, H.L. Vu, J.R. McGhee, and J. Mestecky. 2001. Heterosubtypic immunity to lethal influenza A virus infection requires B cells but not cytotoxic T lymphocytes (CTL). J. Infect. Dis. 183: 368-376.

van Ginkel, F.W., McGhee, J.R., Thomas, O., Campos-Torres, A., and Briles, D.E. 2003.  Pneumococcal carriage results in ganglioside-mediated olfactory tissue infection.  Proc. Natl. Acad. Sci. (USA). 100: 14363-14367.

Szalai, A.J., Weaver, C.W., McCrory, M.A., van Ginkel, F.W., Reiman, R.M., Kearney, J.F., Marion, T.N., and Volanakis, J.E.2003. Lupus is delayed in (NZBxNZW)F1 mice expressing human C-reactive protein. Arthritis  Rheum. 48:1602-1611.

van Ginkel, F.W., Jackson, R.J., Vu, H.L., Yoshino, N., Hagiwara, Y., Metzger, Fujihashi, K., D.J., Connell, T.D., Martin, M., and McGhee, J.R. 2005.  Enterotoxin-based mucosal adjuvants alter antigen trafficking and induce inflammatory responses in the nasal tract.  Infect. Immun. 73:6892-6902.

Duverger, A, Jackson, RJ, van Ginkel, FW, Fischer, R, Tafaro, A, Leppla, SH, Fujihashi, K, Kiyono, H, McGhee, JR, Boyaka, PN.  2006. Bacillus anthracis Edema Toxin Acts as an Adjuvant for Mucosal Immune Responses to Nasally Administered Vaccine Antigens.  J. Immunol. 176:1776-1783.

Joiner, K. S., Hoerr, F. J., Ewald, S. J. , van Santen, V. L., Wright, J. C., van Ginkel, F.W., and Toro, H. 2007. Pathogenesis of infectious bronchitis virus in vaccinated chickens of two different MHC B complex genotypes. Avian Dis. 51: 758-763.

J. Shi, Aono, S, Lu, W., Ouellette, A.J., Hu, X., Ji, Y., Wang, L., Lenz, S., van Ginkel, F.W., Liles, M., Dykstra, C., Morrison, E.E., and Elson, C.O. 2007.   A novel role for defensins in intestinal homeostasis: regulation of IL-1b secretion.  J. Immunol. 179: 1245-1253.

van Ginkel, F.W., Iwamoto, T., Schultz, B.D., and Tomich, J.M. 2008. Immunity to a Self-derived, Channel-Forming Peptide in the Respiratory Tract.  Clin. Vaccine Immunol. 15: 260-266.

van Ginkel, F.W., van Santen, V. L., Gulley, S.L., Toro, H. 2008. Infectious bronchitis virus in the chicken Harderian gland and lachrymal fluid: viral load, infectivity, immune cell responses, and effects of viral immunodeficiency.  Avian Dis.  52: 608-617.

Wang, C., van Ginkel, F.W., Kim, T., Li, D., LI, Y., Dennis, J.C., and Kaltenboeck, B. 2008. Temporal delay of peak T-cell immunity determines Chlamydia pulmonary disease in mice.  Infect. Immun. 49: 13-23.

Niemeyer, G.P., Herzon, R.W., Mount, J.D., Arruda, V.R., Tillson, M., Hathcock, J.T., van Ginkel, F.W., High, K.A. and Lothrop, C.D. 2009. Long Term Correction of Inhibitor Prone Hemophilia B Dogs Treated with Liver-Directed AAV2 Mediated Factor IX Gene Therapy. Blood  113: 797-806.

Wang, L., Shi, J., van Ginkel, F.W., Lan, L., Niemeyer, G., Martin, D.R., Snyder, E.Y., and Cox, N.R. 2009.  Neural progenitor cells modulate T lymphocytes through nitric oxide and prostaglandin E2.  Exp. Neurol. 216: 177-183.

van Ginkel, F.W., Toro, H., Tang, D.C., Gulley, S.L. 2009.  Induction of Mucosal Immunity in the Avian Harderian Gland with a Replication-Deficient Ad5 vector Expressing Avian Influenza H5.  Dev. Comp. Immunol. 33: 28-34.

Toro, H., Effler, J.C., Hoerr, F. J., and van Ginkel, F. W. 2009. Pathogenicity of infectious bursal disease virus variant AL2 in young chickens. Avian Dis. 53:78-82.

 

 

 

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