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Frederik W. van Ginkel, PhD

Dr. Frederik W. van Ginkel is an Associate Professor in the Department of Pathobiology.  He earned his B.Sc. degree in Biology in 1981 and his M.Sc. in Cellular Biology in 1984 at the Agricultural University in Wageningen, the Netherlands. He obtained a Ph.D. in Microbiolgy at the University of Mississippi Medical Center in 1993 after which he pursued a postdoctoral fellowship at the University of Alabama at Birmingham and joined the faculty there in 2000 as a Research Assistant Professor.  He moved to Auburn in 2004 where he is active in research pertaining to mucosal immunology and the training of graduate and professional students.

334-844-0132
vangifw@auburn.edu

Research Interests

My research in the last few years has focused on mucosal immune responses in the respiratory tract to bacterial and viral pathogens and viral vectors.  This research involves two different animal models.  One model measures mucosal immunity in chickens following immunization for avian influenza virus or following exposure to other respiratory chicken viruses.  These studies have focused on the Harderian glands as a mucosal effector site and are analyzing their role in protection to avian pathogens.   The second model analyzes the influence of mucosal immunity and other host factors in pneumococcal colonization of the nasal tract and subsequent invasion of the central nervous system (CNS) in mice.  We previously demonstrated that Streptococcus pneumoniae can directly enter the CNS from the nasal tract without entering the blood bypassing the blood-brain barrier.  We are currently exploring whether or not mucosal immunity to selected pneumococcal targets can prevent pneumococcal invasion into the CNS and nasal colonization.

Selected Publications

van Ginkel, F.W., N.W. Miller, M.A. Cuchens, and L.W. Clem. 1994.  Activation of channel catfish B cells by membrane immunoglobulin  cross-linking.  Dev. Comp. Immunol. 18: 97-107.

van Ginkel, F.W., C-J. Liu, J.W. Simecka, J-Y. Dong, T. Greenway, R.A. Frizzell, H. Kiyono, J.R. McGhee, and  D.W. Pascual. 1995.  Intratracheal gene delivery with adenoviral vector induces elevated systemic IgG and mucosal IgA antibodies to adenovirus and b-galactosidase.  Human Gene Therapy 6 : 895-903.

van  Ginkel, F.W., and D.W. Pascual. 1996  Recognition of neurokinin 1 receptor (NK1-R): an antibody to a peptide sequence from the third extracellular region binds to brain NK1-R . J. Neuroimmunol.  67: 49-58.

van Ginkel, F.W.,H. Kiyono and J.R. McGhee. 1997.  Human  papillomavirus and mucosal immunity in the female reproductive tract. Papillomavirus  Report 8 : 1-10.

Ban, E.M. F.W. van Ginkel, J.W. Simecka, H. Kiyono, H.L. Robinson, J.R. McGhee. 1997. Mucosal immunization with DNA encoding influenza hemagglutinin. Vaccine 15: 811-813.

van Ginkel. F.W., J.R. McGhee, C-J. Liu, J.L. Simecka, R.A. Frizzell, E.J. Sorscher, H. Kiyono, and D.W. Pascual.  1997.  Segregation of CD4 T helper cell responses to Ad5 vector and transgene.  J. Immunol. 159: 685-693.

Yamamoto, S., H. Kiyono, M. Yamamoto, I. Imaoka, M. Yamamoto, K. Fujihashi, Y. Takeda, F.W. van Ginkel, and J.R. McGhee. 1997.  A nontoxic mutant of cholera toxin enhances mucosal immunity.  Proc. Natl. Acad. Sci. USA.  94: 5267-5272.

van Ginkel, F.W.,Jackson, R.J., Yuki, Y., and McGhee, J.R.. 2000. The mucosal adjuvant cholera toxin redirects vaccine proteins into   olfactory tissues.  J. Immunol. Cutting Edge 165: 4778-4782.

Nguyen, H.H, F.W. van Ginkel, H.L. Vu, M.J. Novak, H. Kiyono, J.R.    McGhee, and J. Mestecky. 2000. Gamma interferon is not required for mucosal cytotoxic T lymphocyte responses of heterosubtypic immunity to influenza A virus infection in mice.  J. Virol. 74: 5495-5501.

Nguyen, H.H., F.W. van Ginkel, H.L. Vu, J.R. McGhee, and J. Mestecky. 2001. Heterosubtypic immunity to lethal influenza A virus infection requires B cells but not cytotoxic T lymphocytes (CTL). J. Infect. Dis. 183: 368-376.

van Ginkel, F.W., McGhee, J.R., Thomas, O., Campos-Torres, A., and Briles, D.E. 2003.  Pneumococcal carriage results in ganglioside-mediated olfactory tissue infection.  Proc. Natl. Acad. Sci. (USA). 100: 14363-14367.

Szalai, A.J., Weaver, C.W., McCrory, M.A., van Ginkel, F.W., Reiman, R.M., Kearney, J.F., Marion, T.N., and Volanakis, J.E.2003. Lupus is delayed in (NZBxNZW)F1 mice expressing human C-reactive protein. Arthritis  Rheum. 48:1602-1611.

Briles, D.E., Hollingshead, S.K., Paton, J.C., Ades, E., Novak, L., van Ginkel, F.W., and Benjamin, W.H. Jr. 2003.  The effect of immunity to PspA, PsaA, and pneumolysin on resistance to pneumococcal infection in a murine model of pulmonary infection with Streptococcus pneumoniae.  J. Infect Dis.188: 339-348.

van Ginkel, F.W., Jackson, R.J., Vu, H.L., Yoshino, N., Hagiwara, Y., Metzger, Fujihashi, K., D.J., Connell, T.D., Martin, M., and McGhee, J.R. 2005.  Enterotoxin-based mucosal adjuvants alter antigen trafficking and induce inflammatory responses in the nasal tract.  Infect. Immun. 73:6892-6902.

Duverger, A, Jackson, RJ, van Ginkel, FW, Fischer, R, Tafaro, A, Leppla, SH, Fujihashi, K, Kiyono, H, McGhee, JR, Boyaka, PN.  2006. Bacillus anthracis Edema Toxin Acts as an Adjuvant for Mucosal Immune Responses to Nasally Administered Vaccine Antigens.  J. Immunol. 176:1776-1783.