Molecular virology, viral diseases of poultry, chicken anemia virus, infectious bronchitis virus, host/viral interactions, effect of immunosuppressive viruses on pathogenesis of other infectious agents, viral variation, host selection of viral variants.
The general areas of research interest of our laboratory include avian viral diseases and host/pathogen interaction at both the cellular and organismal levels.
We are currently focusing on effects of immunosuppressive viruses chicken anemia virus (CAV) and infectious bursal disease virus (IBDV) on pathogenesis of other infectious agents, using the respiratory pathogen avian infectious bronchitis virus as a model (IBV). We have found that CAV and IBDV infection each delay the IBV-specific local antibody response, prolong respiratory signs, and increase IBV persistence. However, the extent and kinetics of the effects of each immunosuppressive virus on IBV infection are distinct.
A new focus is IBV and CAV genetic variation and host selection of variants.