Facilitation of diagnostic testing in support of research done by other investigators. Comparative studies of in-office automated instruments. Comparative studies of diagnostic methodologies.
Clinical pathology data represent an essential component of a majority of clinical science, as well as, basic science research projects. I serve as a consultant on experimental design to many principal investigators with regard to clinical pathology research issues.
For my personal projects, clinically applicable results obtained from basic and applied research are of prime interest to me. I try to design relatively small projects that use existing or newly developed/newly available assays/technologies to answer questions that arise concerning old and newly recognized diseases in patients of the CVM Teaching Hospitals. Some recent projects include comparison of three different methods for determination of fibrinogen concentration in horses. Validation of an in-office hematology instrument for use in analysis of body cavity effusions, such that practitioners will have a way to accurately count cells and hopefully obtain a partial differential of the cell types. Comparison of urine protein, creatinine, and protein:creatinine ratio results obtained by three different methods, a newly available urine dipstick, acid-precipitation of protein, and wet chemistry analysis on an automated chemistry instrument. Guidelines suggested from interpretation of these data have been implemented in routine urinalyses in AUCVM and several other universities. Comparison of results from 4 in-office hematology analyzers with results from the Bayer Advia (state-of-the-art automated hematology analyzer in the clin path lab at AUCVM). This information will help practitioners select an in-office hematology instrument that suits their needs.