All research involving the use of animals must be approved by the Auburn University (AU) Institutional Animal Care and Use Committee (IACUC) in keeping with the requirements of the Animal Welfare Act (Public Law 89-544, August 24, 1966, and subsequent amendments), the Health Research Extension Act (Public Law 99-158, November 20, 1985, and subsequent amendments), and the Guide for the Care and Use of Laboratory Animals (1985). Before animals can be used at Auburn University for research, teaching, demonstration, display, breeding, production, or maintenance, the IACUC must review and approve the protocol for the proposed activity. The protocol must be described on the AU Animal Subjects Review Form. A protocol review number PRN) is assigned to approved protocols. A current PRN is required in order to acquire animals, to use facilities for housing of animals, and to use the animals. Written information about requirements for the use of animals is available from the office of the AU Vice President for Research, the Director of Laboratory Animal Resources for AU, and the Director of Laboratory Animal Health at the AU College of Veterinary Medicine. The Director of Laboratory Animal Resources and the Director of Laboratory Animal Health provide orientation/training for all faculty, graduate students, and staff as needed, to ensure compliance with regulations and principles for the utilization and care of vertebrate animals used in research and teaching while facilitating the furtherance of appropriate animal usage with high standards of good laboratory practice.