Frank F. Bartol Alumni Professor of Anatomy, Physiology & Pharmacology, Associate Dean for Research and Graduate Studies, and Interim Director of the Scott-Ritchey Research Center Research focuses on identification of factors affecting and mechanisms regulating development and function of reproductive tract tissues and fertility in domestic animals.
Douglas Martin Associate Research Professor Research focuses on therapeutic strategies for the neuropathic lysosomal storage diseases known as GM1 and GM2 gangliosidosis in well-characterized feline models. [Media]
Tatiana Samoylova Associate Research Professor Research focuses on development of contraceptive vaccines for feral and wild animals using phage display technology.
Bruce F. Smith Professor, Pathobiology Research interests are focused on gene therapy of inherited muscle diseases such as Duchenne muscular dystrophy, gene therapy of cancer and nucleic acid immunization.
Frederik W. van Ginkel Associate Professor, Pathobiology Research focused on mucosal immune responses in the respiratory tract to bacterial and viral pathogens and viral vectors.
Clinical Veterinary Fellow
Ashley Randle, DVM Dr. Randle’s work focuses on translational research for non-rodent models of neurologic disease with major emphasis on Sandhoff Disease in cats and Tay-Sachs Disease in sheep. Dr. Randle oversees the day-to-day care of the animal colonies and all aspects of veterinary care including routine illness management, elective spays/neuters, critical care, induction and maintenance of anesthesia for MRI and CT, and intracranial injections using both stereotactic coordinates and ultrasonographic guidance.
Post Doctoral Fellows
Payal Agarwal, Ph.D. Dr. Agarwal's research interests include gene therapy vector for treatment of canine tumors. This work involves the clinical trials for evaluation of a conditionally replicative adenoviral vector for the treatment of canine osteosarcoma and evaluation of the utility of purine nucleoside phosphorylase for canine cancer therapy.
Heather Gray Edwards, DVM, Ph.D. Dr. Edwards' research interests include: (1) the development of the ideal molecular therapy for animal models of GM1, Sandhoff and Tay-Sachs disease. Currently we are working on the second phase of AAV-mediated gene therapy, which involves optimizing our therapeutic strategy prior to onset of human clinical trials. (2) Establishing methods using high field strength MRI (3 and 7 Tesla), Magnetic Resonance Spectroscopy (MRS) to non-invasively gather biochemical and metabolic information about the brain and to assess efficacy after AAV gene therapy.
Maninder Sandey, Ph.D. Dr. Sandey's research interests include the development of a pan-tumor specific conditionally replicating canine adenoviral vector (CRAd): This project involves the development of a conditionally replicative adenoviral vector that is specifically targeted to replicate and destroy only canine cancer cells. Additionally, he is also investigating the biological properties of various antitumor genes like canine TRAIL (TNF-related apoptosis inducing ligand) and mda-7 for further enhancing the specific antitumor activity of CRAds.
Henry J. Baker Editor-in-Chief, Journal of Veterinary Medical Education Professor Emeritus Pathobiology and Department of Clinical Sciences Research directed toward understanding the pathogenetic basis for neurological dysfunction in lysosomal diseases, characterizing the molecular defect in these fatal inherited diseases of children, dogs and cats, and developing therapeutic and preventative strategies for these incurable diseases.
The late Nancy R. Cox Professor, Pathobiology Director Emeritus Research focuses on pathologic changes in diseases of the central nervous system of cats and dogs to identify, characterize and develop therapies for these diseases. Participant in interdisciplinary research to identify and characterize genetic abnormalities of cats that result in neurologic diseases such as the gangliosidoses. Participant in research to develop new injectable and oral contraceptives to control overpopulations of dogs, cats, and other species.
Steven F. Swaim Professor Emeritus Department of Clinical Sciences Research directed toward development and evaluation of new reconstructive surgical procedures to correct problem wounds encountered by veterinary practitioners and research on the prevention and treatment of problem wounds in both humans and animals.