Case Name: Lymphoma Signalment: 6-year old spayed female Golden retriever Presenting Complaint and Patient History: The dog is lethargic and has a decreased appetite.  Generalized peripheral lymph node enlargement has been present for ~2 weeks.  She recently developed a mild, nonproductive cough. Physical Examination: T=100.6, HR = 108 bpm, RR = pant.  The dog is depressed but responsive.  There is marked peripheral lymph node enlargement.  No other abnormalities are detected. Cytology Images: lymph node cytology 2 lymph node cytology 1   Cytology Description Smears made of needle aspirates from the mandibular lymph node are highly cellular.  Most of the cells are large immature lymphocytes that have a loose chromatin pattern with multiple prominent nucleoli.  Mitotic activity appears to be slightly increased.  A few small mature lymphocytes are also seen, and a moderate number of peripheral blood cells are present in the background. Opinion:  Large cell lymphoma Histopathology Images: Histopathology Description pending Diagnostic Imaging Studies: lateral thorax V/D thorax   Thoracic radiographs are unremarkable.  On abdominal ultrasound (not shown) there is moderate enlargement of the mesenteric lymph nodes and the spleen is diffusely hyperechoic. Supporting Documentation (lab results, etc.) Search File Description Date Uploaded Hematology  ·  pdf/4kB 3/30/2008 Chemistry panel  ·  pdf/4kB 3/30/2008 urinalysis  ·  pdf/3kB 3/30/2008