Case Name: Case 1 - Transitional Cell Carcinoma Signalment: 13-year old female spayed Beagle Presenting Complaint and Patient History: Recent onset of hematuria and stranguria. Physical Examination: The dog is slightly obese, with a body condition score of 7/9.  There is a large amount of dental tartar.  Physical examination is otherwise within normal limits. Cytology Images: impression smear - 20X Impression smear - 100X   Cytology Description An impression smear made from a cystoscopic biopsy of a mass in the urinary bladder contains sheets of large epithelial cells that show moderate to marked anisocytosis and anisokaryosis with frequent binucleation. Opinion:  Carcinoma, presumably transitional cell carcinoma of the urinary bladder Histopathology Images: H&E, 10X H&E, 40X   Histopathology Description H&E, 10X: Fragments of the mass are composed of groups of pleomorphic, polygonal cells supported by a scant, fibrovascular stroma, with formation of microcysts. H&E, 40X: Cells of the mass are polygonal in shape and have distinct cell borders, anisokaryotic nuclei with clumped chromatin and 1-3 nucleoli. Occasional binucleated cells are present. Diagnosis: Transitional cell carcinoma Diagnostic imaging Ultrasound - urinary bladder Radiograph - lateral abdomen   Description Radiographs: The urinary bladder is enlarged.  A mineral opacity is present in the stomach, and a large amount of gas is seen throughout the GI tract. Abdominal ultrasound: Two masses are seen arising from the wall of the urinary bladder. Supporting Documentation (lab results, etc.) Search File Description Date Uploaded Urinalysis  ·  pdf/4kB PDF 2/4/2008