Faculty Research Interests H.J. BAKER Professor, Scott Ritchey Research Center Inherited metabolic diseases; mammalian molecular genetics; animal models of human diseases; pathogenesis and therapy of lysosomal storage diseases; inherited diseases of companion animals; gene therapy.   E. BEHREND Assistant Professor, Clinical Sciences My laboratory research focusses on the mechanism of negative feedback in corticotrophs, i.e. how glucocorticoids inhibit ACTH secretion. Studies focus on Dexras1, a gene cloned by Dr. R. Kemppaninen, that belongs in the Ras superfamily of proteins and may be involved in feedback.  For clinical research, projects include evaluation of hypophysectomy for treatment of canine Cushing's syndrome and clinical endocrine diagnostics for dogs and cats.   R.C. BIRD Professor, Pathobiology Molecular genetics of eukaryotic cell cycle regulation; gene expression and regulation; regulatory mechanisms involving oncogene and tumor suppressor gene mediated transformation and cell cycle control; subtractive cDNA library construction representing single cell cycle phases.   B.L. BLAGBURN Professor, Pathobiology Immunology, development, pathogenesis, ultrastructure, and in vitro cultivation of parasitic protozoa (i.e., Cryptosporidium, Eimeria, Isospora, Toxoplasma, Neospora, Sarcocystis); chemotherapy of parasitic helminths and arthropods.   M.K. BOUDREAUX Associate Professor, Pathobiology Congenital and acquired platelet function defects; comparative platelet pathophysiology; congenital and acquired disorders of coagulation proteins.   T.D. BRADEN Associate Professor, Reproductive Endocrinology,  Anatomy, Physiology & Pharmacology Regulation of the sensitivity of endocrine organs to effectors. Mechanisms of action and signal transduction pathways of protein and peptide hormones. Regulation of estrous cycles in domestic species.   C.E. BRANCH Professor, Anatomy, Physiology & Pharmacology Development of evaluation of multimedia programs for use in teaching physiology in the health professions and teaching in other areas of veterinary medicine, including continuing education.   C.J. BRUNNER Associate Professor, Pathobiology Clinical and applied immunology; tumor immunology; fish immunology.   E. COLEMAN Associate Professor, Anatomy, Physiology & Pharmacology Neuroscience/neurotoxicology: more specifically, the role of astrocytes in central nervous system dysfunction linked to neurologic, metabolic, and toxic disorders.   N.R. COX Interim Director, Scott Ritchey Research Center Neuropathology; comparative pathology; animal models of human diseases.   G.H. D'ANDREA Affiliate Assistant Professor, State Diagnostic Laboratory Diagnostic toxicology; toxicologic pathology.  S.J. EWALD Professor, Pathobiology Thymocyte differentiation and signal transduction, and effects of ethanol on these processes; modulation of avian immune responses by Mycoplasma gallisepticum and M. synoviae; immunological basis of genetic resistance to Marek's disease in chickens.   J.J. GIAMBRONE Adjunct Professor, Poultry Sciences Diagnosis, treatment, and control of economically important diseases of poultry utilizing molecular biological techniques.   M.D. GIVENS Research Assistant Professor Research focuses on understanding and preventing the transmission of viral pathogens by reproductive events.  Specific areas of research include detection of bovine viral diarrhea virus in in vitro embryo production systems, detection of bovine viral diarrhea virus in extended semen samples, and use of anti-viral agents in bovine in vitro embryo production systems.   C.M. HENDRIX Associate Professor, Pathobiology Parasite/host interactions; canine heartworm disease.   R.A. HENDERSON Professor, Clinical Sciences Interests are primarily in the area of response of spontaneous animal neoplasms to various treatments. A second interest area is the effectiveness of preoperative radiation for reducing tumor volume to facilitate complete excision of local neoplasms.   F.J. HOERR Professor, State Diagnostic Laboratory Avian diseases; avian pathology; mycotoxicoses; diagnostic techniques.     MICHAEL H. IRWIN Research Associate Professor and Director, AU Transgenic Facility, Pathobiology Animal transgenesis and modeling of human disease; mitochondrial genetics E.M. JOSEPHSON Assistant Professor, Anatomy, Physiology and Pharmacology Synaptic connections that allow sensory integration in the olfactory and auditory systems, using immunohistochemical techniques, and light, confocal and electron microscopy. Currently, my lab is studying the expression of glutamate transporters in relation to synaptic junctions in the olfactory bulb, and the role of transporters in neurotransmitter diffusion between axon terminals. Their expression and function may be critical to information exchange between neurons and the development of excitotoxic lesions in the  central nervous system.   R.L. JUDD Associate Professor; Anatomy, Physiology and Pharmacology Biochemical and endocrine pharmacology; Characterization of the effects of antidiabetic agents (sulfonylureas, biguanides, thiazolidinediones) and leptin n hepatic glucose metabolism and specific regulatory enzymes involved in intermediary metabolism; Investigations into the metabolic ameliorations in glucose and fat metabolism which result in the physiological expression of type 2 diabetes.   B. KALTENBOECK Assistant Professor, Pathobiology Molecular biology of Chlamydia infection and pathogenesis. Genetic analysis of outer membrane protein genes and investigation of speciation in Chlamydia species.   B.W. KEMPPAINEN Professor, Anatomy, Physiology & Pharmacology Health effects of fungal toxins. Development and refinement of in vitro systems which can be used to screen chemicals for their toxic effects and study the mechanism of action of toxins.   R.J. KEMPPAINEN Professor, Anatomy, Physiology & Pharmacology Positive and negative regulation of adrenocorticotropin secretion; intracellular mechanisms of steroid negative feedback. Identification of steroid-induced protein using one- and two-dimensional electrophoresis, measurement of transient changes in intracellular calcium concentrations using fluorescent calcium chelators, stimulus-secretion coupling in pituitary cells, and the use of cell perifusion to study dynamic changes in secretion.   S.A. KINCAID Professor, Anatomy, Physiology & Pharmacology Pathobiology of bones and joints; Studies in cartilage, bone as related to diseases, growth and development. P.H. KLESIUS Affiliate Professor, USDA Fish Parasitology Unit Health and immunity of cultured fish; characterization of humoral and cellular immune responses and enhancement of these responses to produce vaccines; development of rapid diagnostic techniques.   D.K. MACINTIRE Professor, Clinical Sciences Interests are in hemodynamic effect of prazosin HCL in dogs with dirofilariasis, study of safety and efficacy of a blood substitute product in anemic dogs, and low dose intravenous insulin infusion for treatment of diabetic ketoacidosis. E.E. MORRISON Professor, Anatomy, Physiology & Pharmacology Neurobiology of Chemosensory Systems; Special interest in development and plasticity of olfactory neurons; Disease transmission in the channel catfish   L.J. MYERS Associate Professor, Anatomy, Physiology & Pharmacology Dr. Myers' research centers around investigations into the sensory capabilities of animals and biophysical/biochemical mechanisms within the olfactory system, particularly as these relate to the development of biosensor systems. His research has been supported by the Federal Aviation Administration, the Department of the Treasury, the Department of Defense, and others.    J.C. NEWTON Associate Professor, Pathobiology Pathogenesis of bacterial diseases of fish; analysis of virulence determinants of Edwardsiella ictaluri; canine and equine pythiosis.   L.P. NUEHRING Affiliate Assistant Professor, State Diagnostic Lab Tibial dyschondroplasia and other skeletal diseases.   K.E. NUSBAUM Associate Professor, Pathobiology Infectious diseases of food animals and fish.   V. PETRENKO Professor, Pathobiology Research Interests:  Phage display; substitute antibodies:diagnostics, detectors. Engineering of genes, proteins and microorganisms.  Molecular evolution. Protein drug design. Current research programs:  1.  Genetically engineered micro-fabrication of bio-selective layers in biosensors for detection of microbial and toxic threat agents: 2.  Targeting the cancer cells. 3.  Probes for detection of prohibited meat and bone meal in animal feed.   CARL A. PINKERT Professor, Pathobiology and Associate Dean for Research and Graduate Studies Animal transgenesis; mitochondrial genetics and molecular medicine; animal modeling of human disease J.A. PLUMB Adjunct Professor, Fisheries & Allied Aquaculture Viral and bacterial diseases of fish; aquaculture.  S.B. PRICE Associate Professor, Pathobiology Molecular biology of bacterial pathogens; microbiology of host/parasite interactions. Analysis of virulence determinants of Yersinia pestis, the causative agent of bubonic plague, and Pasteurella multocida, the etiologic agent of fowl cholera.   E.A. SARTIN Associate Professor, Pathobiology Tumor pathobiology; reproductive hormones in primary mammary tumors and cell lines; neurofibromatosis; skin and reproductive pathology.   J.L. SARTIN Professor, Anatomy, Physiology & Pharmacology Regulation of growth hormone secretion and gene expression, particularly with reference to signal transduction mechanisms in the anterior pituitary gland. The relationship between the endocrine system and disease, with emphasis on the effects of disease on hormone secretion and the effects of hormones on the progression of diseases.   D.D. SCHWARTZ Associate Professor, Anatomy, Physiology & Pharmacology Adrenergic and peptide receptor mediated signal transduction pathways involved in cardiovascular function. Investigation of intracellular mechanisms of stimulus secretion coupling and vascular reactivity.   B.F. SMITH Associate Professor, Scott Ritchey Research Center Molecular basis of inherited disease; animal models of human disease; methods of gene transfer and gene therapy, with emphasis on muscle and myopathies; muscle specific gene expression.   D.A. STRINGFELLOW Professor, Pathobiology Clinical and laboratory applications of in vitro fertilization in cattle; embryo-pathogen interactions; epidemiology of embryo transfer.    V.L. VAN SANTEN Associate Professor, Pathobiology Regulation of eukaryotic and viral gene expression; molecular virology; structure and function of immediate early genes of bovine herpesvirus 4; cloning and overexpression of Mycoplasma synoviae avian immunoglobulin binding protein gene.   V. VODYANOY Professor, Anatomy, Physiology & Pharmacology Sensory physiology, biophysics of odor detection, receptors, reconstitution of membrane associated macromolecules.   R.C. WEISS Associate Professor, Pathobiology Tumor pathobiology and immunology. Cell adhesion molecules and metastasis. Immunomodulation of host tumor responses.    E.G. WELLES Associate Professsor, Pathobiology Coagulation and fibrinolysis; clinical pathology.   R.D. WHITLEY Professor, Clinical Sciences The effect of HO:YAG laser on the cornea, biocompatibility of synthetic materials within the eye, pathophysiology of keratoconus, cataract removal by phacofragmentation and surgical management of glaucoma.   J.C. WRIGHT Associate Professor, Pathobiology Epidemiology of infectious diseases; transmission of vector-borne diseases; prevention and control of zoonoses.   J. ZHONG Associate Professor Cardiovascular muscle cell electro-physiology. Current research is focused on the signaling transduction pathways underlying modulation of calcium channels in both cardiac and vascular smooth muscle cells using patch-clamp technique