Tatiana Samoylova, M.S., Ph.D. Dr. Tatiana I. Samoylova received her MS degree in Botany and Zoology from Kiev State University (Kiev, USSR) in 1982 and her PhD in Biochemistry from the Institute of Experimental Botany (Minsk, USSR) in 1991. She was a postdoctoral research associate at the Department of Molecular Genetics, Institute of Plant Genetics and Crop Plant Research (Gatersleben, Germany) from 1994 to 1996. Later in 1996, she moved to the United States and joined Scott-Ritchey Research Center (CVM, Auburn University) as a Postdoctoral Fellow working on development of targeted therapies for muscle and brain diseases. Dr. Samoylova continued to work at the Center as an Assistant Research Professor from 1999 to 2004. Since October 2004 she has been an Associate Research Professor. She is a biochemist with many years of experience in the design and use of therapeutic/diagnostic peptides and proteins. In addition to multiple publications, she holds four patents in the area of design and application of phage display-derived peptides for targeted delivery of therapeutic and diagnostic agents to various types of cells and tissues. Her honors and awards include Diploma with Honor in Botany and Zoology (Kiev State University, 1982), Named Research Fellowship, Muscular Dystrophy Association (1998-1999); her biography is published in Who's Who in America, Who's Who in Veterinary Medicine Higher Education, Who's Who in Science and Engineering (2004-present).
334-844-5569 samoiti@vetmed.auburn.edu
Research Interests Dr. Samoylova’s research focuses on two major areas: (1) development of peptides for targeted brain gene/drug therapies and (2) generation of recombinant proteins for enzyme replacement therapy for neuronopathic lysosomal storage diseases.To develop targeted therapies, she utilizes phage display technology. This technology, which uses combinatorial libraries of peptides expressed on phage particles, has the potential needed for development of patient-specific anti-cancer agents for brain tumors, gliomas. Neurodegenarative diseases, in particular lysosomal storage disorders, are the most recent of her research interests. Some of these disorders can be effectively treated with only a small increase in functional enzymatic levels above the deficient state, achievable by enzyme replacement and/or gene therapies. She is testing new approaches for the use of enzyme replacement /gene therapies in GM1 gangliosidosis, a lysosomal storage disease caused by beta-galactosidase deficiency. Recent Publications Samoylova TI, Martin DR, Morrison NE, Hwang M, Cochran AM, Samoylov AM, Baker HJ, Cox NR. Generation and characterization of recombinant feline β-galactosidase  for preclinical enzyme replacement therapy studies in GM1 gangliosidosis (Metabolic Brain Disease, accepted). Brigati J, Samoylova T, Jayanna P, Petrenko V. Phage display for  generating peptide reagents. Unit 18.9 in Current Protocols in Protein Science, John Wiley & Sons, Inc. (in press, 2008). Selz KA, Samoylova TI, Samoylov AM, Vodyanoy VJ, Mandell AJ. 2007.  Designing allosteric peptide ligands targeting a globular protein. Biopolymers, 85(1):38-59. Samoylova T.I., Morrison N.E., Globa L.P., Cox N.R. 2006. Peptide phage display: opportunities for development of personalized anti-cancer strategies. Anti-Cancer Agents - Med. Chem., 6(1):9-17. Samoylova TI, Cox NR, Morrison NE, Globa LP, Romanov V, Baker HJ, and Petrenko VA. Phage matrix for isolation of glioma cell-membrane proteins. 2004. BioTechniques, 37(2):254-260. MountJ, Samoylova T, Morrison N, Cox N, Baker H, and Petrenko V. Cell targeted phagemid rescued by pre-selected landscape phage. 2004. Gene, 41:59-65. Samoylova TI, Morrison NE, and Cox NR. Molecular markers of glial tumors: Current targeting strategies. 2003. Current Medicinal Chemistry, 10, 1241-1253. Samoylova TI, Petrenko VA, Morrison NE, Globa LP, Baker HJ, and Cox NR. Phage probes for molecular profiling of malignant glial cells. 2003. Molecular Cancer Therapeutics, 2:1129-1137. Samoylova TI, and Smith BF. 2002. Identification of cell targeting ligands using random peptide-presenting phage libraries. In Genetic Library Construction and Screening. Advanced Techniques and Applications. C. Bird and B. Smith, eds., Springer-Verlag, Heidelberg, pp.209-231. Samoylova TI, Ahmed BY, Vodyanoy V, Morrison NE, Samoylov AM, Globa LP, Baker HJ, and Cox NR. Targeting peptides for microglia identified via phage display. 2002. J. NeuroImmunology, 127:13-21.