Vitaly J. Vodyanoy, MS, PhD Professor of Physiology and Director of Biosensor Laboratory, joined the College of Veterinary Medicine in 1989. Dr. Vodyanoy received his M.S. in Physics from Moscow Physical Engineering Institute in 1964, and his Ph.D. in biophysics in 1973 from Agrophysical Research Institute, Leningrad, USSR. He has been a member of the faculty in the Institute of Semiconductors and A.F. Loffe Physicotechnical Institute, Academy of Sciences, Leningrad, USSR. He had worked at the Department of Chemistry, New York University and the Department of Physiology and Biophysics, College of Medicine, University of California, Irvine.
334-844-4425 vodyavi@vetmed.auburn.edu
Research Intrests Sensory physiology, biophysics of odor detection, receptors, reconstitution of membrane associated macromolecules. The major research aims are to determine the initial chemoreceptive events in the animal olfactory system and to find out how is odorant information translated into electrical events in the olfactory receptor. The work involves the transfer of macromolecules from olfactory receptor cells into artificial bimolecular membranes, monolayer and multilayers, and studying the electrical and chemical properties of the reconstituted systems. Another focus of this research is the use of functional reconstitution of the olfactory receptor cell to produce an artificial system responsive to small (subnanomolar) concentrations of odorant. The objective of this study is to develop a working prototype of an electrochemical sensor which shares basic molecular mechanisms associated with the initial steps in olfaction. We are also studying glutamate receptors reconstituted in bilayers using a combination of patch clamp and biochemical techniques. The main focus of this work is to determine molecular mechanisms of the specific facilitation of electrical activity of some of these receptors involved in the information storage (memory) in the brain. Selected Publications Alexander M. Samoylov, Tatiana I. Samoylova, Oleg M. Pustovyy, Alexei A. Samoylov, Maria A. Toivio-Kinnucan, Nancy E. Morrison, Ludmila P. Globa, William F. Gale and Vitaly Vodyanoy.  (2005)  Novel metal clusters isolated form blood are lethal to cancer cells.  Cells, Tissues Organs 179(3):115-124. AM Samoylov, TI Samoylova, OM Pustovyy, AA Samoylov, MA Toivio-Kinnucan, NE Morrison, LP Globa, WF Gale, and V Vodyanoy.  (2004)  Anti-tumor extracts isolated from shark tissue.  Molecular Biology of the Cell 15:253A-253A 1398 Suppl. S. Jennifer Cannon Sykora, William C. Neely and Vitaly Vodyanoy.  (2004)  Thermodynamic characteristics of mixed monolayers of Amphotericin B and cholesterol.  Journal of Colloid and Interface Science 276(1):60-67. EM Josephson, S Yilma, V Vodyanoy and EE Morrison.  (2004)  Structure and function of long-lived olfactory organotypic cultures from postnatal mice.  Journal of Neuroscience Research 75(5):642-653. Jennifer Cannon Sykora, William C. Neely and Vitaly Vodyanoy.  (2004)  Solvent effects on Amphotericin B monolayers.  Journal of Colloid and Interface Science 269(2):499-502. EV Olsen, ST Pathirana, AM Samoylov, JM Barbaree, BA Chin, WC Neely, and V Vodyanoy.  (2003)  Specific and selective biosensor for Salmonella and their detection in the environment.  The Journal of Microbiological Methods 53(2):273-285. Jennifer Sykora, Solomon Yilma, William C. Neely and Vitaly Vodyanoy.  (2003)  Amphotericin B and Cholesterol in Monolayers and Bilayers.  Longmuir 19:858-864. VA Petrenko and VJ Vodyanoy.  (2003)  Phage display for detection of biological threat agents.  The Journal of Microbiological Methods 53:253-262. Alexandre M. Samoylov, Tatiana I. Samoylova, Suram T. Pathirana, Ludmila P. Globa and Vitaly J. Vodyanoy.  (2002)  Peptide biosensor for recognition of cross-species cell surface markers.  Journal of Molecular Recognition 15:197-203. Alexandre M. Samoylov, Tatiana I. Samoylova, Mark G. Hartell, Suram T. Pathirana, Bruce F. Smith, and Vitaly J. Vodyanoy.  (2002)  Recognition of cell-specific binding of phage display derived peptides.  Biomolecular Engineering 18:269-272. TI Samoylova, BY Ahmed,  V Vodyanoy, NE Morrison, AM Samoylov, LP Globa, HJ Baker, NR Cox.  (2002)  Targeting peptides for microglia identified via phage display.  NeuroImmunology 127:13- 21. V Suppiramaniam, BA Bahr, S Sinnarajah, K Owens, G Rogers, SYilma, and V Vodyanoy.  (2001)  Member of the ampakine class of memory enhancers prologs the single channel open times of reconstituted AMPA receptors.  Synapse 40:154-158. S Sinnarajah, CW Dessauer, D Srikumar, J Chen, J Yuen, J Dennis, S Yilma, EE Morrison, V Vodyanoy and JH Kehrl.  (2001)  RGS2 inhibits Gsa signaling by impairing activation of type III, V, and VI adenylyl cyclases.  Nature 409:1051-1055. For a complete list of publications, visit https://fp.auburn.edu/vetmed/vvgroup/vv/articles.aspx