Lauren G. Wolfe

phone: 334-844-4539
email: wolfelg@vetmed.auburn.edu

Dr. Wolfe is Professor and Head of the Department of Pathobiology. He holds DVM, MS, and PhD degrees from The Ohio State University and is board-certified in veterinary pathology by the American College of Veterinary Pathologists. Subsequent to receiving his PhD degree in 1968, Dr. Wolfe was a faculty member in the Department of Microbiology at Rush Medical College/Rush-Presbyterian-St.Luke's Medical Center in Chicago for 13 years, attaining the rank of Professor in 1974, and was a Professor in the Graduate College, University of Illinois at the Medical Center from 1975 to 1981. He came to Auburn in 1981 as Head of the Department of Pathology and Parasitology and then in 1988 became Head of the Department of Pathobiology, a new department formed through merger of the Departments of Microbiology and Pathology and Parasitology. Dr. Wolfe's research interests over the years have centered on human viral hepatitis A, biological studies of oncogenic primate herpesviruses and retroviruses, and pathobiology of canine cancer. He has served on several national research review panels, has authored or co-authored over 100 research publications, and has extensive experience in directing students' programs of graduate study and research.

Research Interests

The major efforts of my research group are focused on tumor-associated antigens (TAA) in canine cancer. We have generated a number of monoclonal antibodies (MAbs) which recognize TAA expressed by selected tumor types. Ongoing projects involve characterization of TAA, modulation of antigenic expression by biological response modifiers, and antibody-targeted delivery of therapeutic agents. Resource development is a continuing effort of our group with regard to establishment of tumor cell lines (about 30 established to date), generation of MAbs to TAA, and maintaining a bank of serum samples from cancer patients.

Selected Publications

Oliver JL III, Wolfe LG. Antigen expression in canine tissues, recognized by a monoclonal antibody generated against canine melanoma cells. Am J Vet Res 1992; 53:123-128.

Sartin EA, Barnes S, Toivio-Kinnucan M, Wright JC, Wolfe LG. Heterogenic properties of clonal cell lines derived from canine mammary carcinomas and sensitivity to tamoxifen and doxorubicin. Anticancer Res 1993; 13:229-236.

Ahern TE, Bird RC, Church Bird AE, Wolfe LG. Overexpression of c-erbB-2 and c-myc but not c-ras, in canine melanoma cell lines, is associated with metastatic potential in nude mice. Anticancer Res 1993; 13:1365-1372.

Liu KX, Church Bird AE, Lenz SD, McDonough SP, Wolfe LG. Antigen expression in normal and neoplastic canine tissues defined by a monoclonal antibody generated against canine mesothelioma cells. Vet Pathol 1994; 31:663-673.

Whitley EM, Church Bird AE, Zucker KE, Wolfe LG. Modulation by canine interferon-gamma of major histocompatibility complex and tumor-associated antigen expression in canine mammary tumor and melanoma cell lines. Anticancer Res 1995; 15:923-930.

Wang J, Brunner CJ, Gangopadhyay A, Church Bird A, Wolfe LG. Detection of tumor-associated antigens in sera of canine cancer patients by monoclonal antibodies generated against canine mammary carcinoma cells. Vet Immunol Immunopathol 1995; 48:193-207.