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October 17 @ 11:00 am - 12:00 pm
Alfredo Antonio Ulloa-Aguirre, scientific director, RAI, National University of Mexico, will present a 2018 Joy Goodwin Lecturer on “Misfolded GPCRs and disease: the case of the gonadotropin-releasing hormone and the follicle-stimulating hormone receptors” Wednesday, Oct. 17, in 230 Greene Hall.
Ulloa-Aguirre, M.D., D.Sc., is a member of National Academy of Medicine, Mexico and The Academy of Sciences, Mexico, is a physician-scientist, internationally-recognized leader in the reproductive endocrinology area for his studies on the structure-function relationships of pituitary gonadotropins, gonadotropin receptors, and the gonadotropin-releasing hormone (GnRH) receptor.
His current research interestsinclude: (1) the study of molecular and biochemical aspects of the pituitary gonadotropins, with special focus on the role of follicle-stimulating hormone (FSH) glycans in ligand-receptor interaction and intracellular signaling; (2) the molecular study of naturally occurring mutations
leading to misfolded gonadotropin-releasing hormone and FSH receptors as a cause of disease in humans, and their response to pharmacological chaperones; and; (3) the study of the mechanisms subserving the intracellular traffic of gonadotropin receptors in health and disease, employing a variety of experimental approaches including mutagenesis, gene silencing, and molecular dynamics simulations.
He is currently the scientific director of the Research Support Network (Core Facility) of the National University of Mexico (UNAM)-Mexican National Institutes of Health Consortium, in Mexico City, full-time Senior Scientist of the UNAM, and Emeritus Scientist of the National Research System (SNI-CONACyT) of Mexico.