Kristine Griffett, PhD

Assistant Professor, Pharmacology

Auburn Universtiy Logo
Contact
 

app@vetmed.auburn.edu

Department of Anatomy, Physiology and Pharmacology

Auburn University
College of Veterinary Medicine
1130 Wire Road
Auburn, AL 36849

Education

 

Ph.D., University of South Florida, Tampa, FL
M.S., C.W. Post – Long Island University, Brookville, NY
B.S., St. Joseph’s College, Patchogue, NY

Biography

 

Dr. Griffett joined the faculty at Auburn University in 2022. She received her B.S. in Biology from St. Joseph’s College in New York and went on to pursue her M.S. in Biology degree from the C.W. Post campus of Long Island University. During these studies, Dr. Griffett served as a volunteer emergency medical technician in her community ambulance company. She took a semester off after graduating with her master’s degree to teach undergraduate courses at several colleges on Long Island then moved to Tampa, FL to pursue her Ph.D. from the University of South Florida in Developmental Genetics. Here, Dr. Griffett worked with zebrafish to uncover genomic regions leading to instability, increased somatic mutations and cancer. She then began a postdoctoral fellowship at the Scripps Research Institute in Jupiter, FL under the mentorship of Dr. Thomas Burris in molecular therapeutics and nuclear receptor pharmacology. The lab moved to Saint Louis University School of Medicine, where she was awarded an NIH NURSA F32 award for her work with the Liver X Receptors (LXRs) and Fatty Lover Diseases and completed her postdoctoral training. Dr. Griffett became a research assistant professor at SLU and was awarded an American Heart Association Scientist Development Grant on her work with LXRs and cholesterol. She transitioned to a non-tenure track position within the Center for Clinical Pharmacology at Washington University in St. Louis and the University of Health Sciences and Pharmacy. Dr. Griffett has a certification in Clinical Pharmacology from the NIH that was completed in 2018.

Research Interests

 

Dr. Griffett’s research interests focus on characterizing novel compounds targeting nuclear receptors that can be optimized and further developed for therapeutics.  Using small molecule compounds, her lab can elucidate the role of nuclear receptors in physiology and disease.  Dr. Griffett utilizes a myriad of techniques and animal models to characterize compounds and works collaboratively with medicinal and computational chemists, clinicians, and structural biologists.

Projects include:

  • Developing Non-Opioid Therapeutics for Chronic Pain Conditions (REV-ERB Receptors)
  • Discovering Novel Therapies for NAFLD, NASH, and Metabolic Disease (LXRs, REV-ERBs, FXR, PPAR)
  • Utilizing Chemical Biology Approaches to Characterize Small Molecules for CNS Cancers (TLX)

Teaching Responsibilities

 

Physiology II (Gastrointestinal Physiology)

Publications

 

NCBI: Kristine Griffett Bibliography

ORCID: Kristine Griffett ORCID

Website: Griffett Lab

Twitter: @kgriff716