Kristine Griffett, PhD

Education

B.S., 2004, St. Joseph’s College, Patchogue, NY
M.S., 2006, C.W. Post – Long Island University, Brookville, NY
Ph.D., 2011, University of South Florida, Tampa, FL

Professional Experience

Postdoctoral Fellow, Scripps Research Institute
Postdoctoral Fellow, Saint Louis University School of Medicine
Research Assistant Professor, Saint Louis University School of Medicine
Assistant Professor, Center for Clinical Pharmacology, Washington University in St. Louis & University of Health Sciences & Pharmacy

Biography

Dr. Griffett joined the faculty at Auburn University in 2022. Dr. Griffett began a postdoctoral fellowship at the Scripps Research Institute in Jupiter, FL under the mentorship of Dr. Thomas Burris in molecular therapeutics and nuclear receptor pharmacology. The lab moved to Saint Louis University School of Medicine, where she was awarded an NIH NURSA F32 award for her work with the Liver X Receptors (LXRs) and Fatty Lover Diseases and completed her postdoctoral training. Dr. Griffett became a research assistant professor at SLU and was awarded an American Heart Association Scientist Development Grant on her work with LXRs and cholesterol. She transitioned to a non-tenure track position within the Center for Clinical Pharmacology at Washington University in St. Louis and the University of Health Sciences and Pharmacy. Dr. Griffett has a certification in Clinical Pharmacology from the NIH.

Dr. Griffett’s research interests focus on characterizing novel compounds targeting nuclear receptors that can be optimized and further developed for therapeutics. Using small molecule compounds, her lab can elucidate the role of nuclear receptors in physiology and disease. Dr. Griffett utilizes a myriad of techniques and animal models to characterize compounds and works collaboratively with medicinal and computational chemists, clinicians, and structural biologists. Projects include: Developing Non-Opioid Therapeutics for Chronic Pain Conditions (REV-ERB Receptors), Discovering Novel Therapies for NAFLD, NASH, and Metabolic Disease (LXRs, REV-ERBs, FXR, PPAR), and Utilizing Chemical Biology Approaches to Characterize Small Molecules for CNS Cancers (TLX)

Research Interests

Nuclear Receptors, Chemical Biology, Cardiometabolic Diseases, Pain, NAFLD/NASH

Academic Areas

Physiology, Pharmacology

Key Words

Nuclear Receptors, Drug Discovery, Metabolic Disease, Chronic Inflammation, Pain

Publications and Links

NCBI: Dr. Griffett Bibliography

ORCID: Dr. Griffett

Website: Nuclear Receptors & Chemical Biology

Twitter: @kgriff716