2020 Phi Zeta Research Emphasis Day

Wednesday, November 4, 2020

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8:00am  |  Opening Statement  |  Dr. Skip Bartol

8:05am-11:00am  |  Morning Presentations

11:05am-11:10am  |  Presentation of the Zoetis Research Award

11:10am-12:00pm  |  Joy Goodwin Lecture  |  Dr. Doug Martin
Gene Therapy Trials (and Tribulations) for Neurologic Disease

12:00pm-1:30pm  |  Poster Presentations  |  Online

1:30pm-4:00pm  |  Afternoon Presentations

4:00pm-5:00pm  |  Keynote Lecture  |  Dr. Doug Martin
Gene Therapy and One Health: Are We There Yet?

5:00pm  |  Induction of New Phi Zeta Members & Awards Presentations

View Abstracts

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Undergraduate Student

8:05am  |  Kathryn Wolfe  |  Presentation
Systematic Review of Literature Containing Quality of Anesthetic Induction and Recovery Scales used in Dogs to Assess for Validity and Applicability

Veterinary Students

8:17am  |  Virginia Aida
Efficacy and immunogenicity of a novel subunit influenza vaccine in pigs against an H1N2 field strain

8:29am  |   Casey Phillips
Investigation of Platelet Parameters in Dogs with Hematological Neoplasia

Graduate Students

8:41am  |   Ferrin Antony
Interleukin-27 regulates corneal immunopathology and viral clearance during Herpes Simplex Virus-I infection

8:53am  |   Sophie Boorman
Comparison of the efficacy of 2% mepivacaine and a solution of 2% lidocaine/epinephrine administered for median and ulnar nerve blocks in horses with naturally occurring forelimb lameness

9:05am  |   Serena Ceriotti
Assessment of age-related β2-adrenergic receptors signaling activity in the equine respiratory tract: preliminary results

9:17am  |   Ethan Hefner
Comparison of the Image Quality From Optical Coherence Tomography of the Equine Cornea and Retina Using Sedation and General Anesthesia Protocols With or Without the Use of Retrobulbar Anesthesia

9:29am  |   Karly Hicks
Genomic and in vitro pharmacodynamics analysis of rifampicin resistance at clinically relevant concentrations in multi-drug resistant canine Staphylococcus pseudintermedius isolates

9:41am  |  Anna Huskey
CEACAM gene family mutations associated with increased risk for inherited breast cancer – a comparative genetics approach in dogs and humans

9:53am  |  Zubair Khalid
Enhanced Protection by Recombinant Newcastle Disease Virus Expressing Infectious Bronchitis Virus Spike Ectodomain and GM-CSF

10:05am  |  Shune Kimura
Evaluation of Orally and Rectally Administered Misoprostol in a Low-Dose Endotoxin Challenge in Horses

10:17am  |  Steven Kitchens
Chicken Embryo Lethality Assay for Salmonella Newport

10:29am  |  Troy LoBue
More Evidence for RNASEL:p.Glu265*, A Potential Genetic Modifier of Early-Onset Breast Cancer for Carriers of High-Risk Mutations

10:41am  |  Anne Maguire
Clinical metrics and whole-slide image analysis demonstrate that intravenous AAV gene therapy slows neurodegeneration in feline Sandhoff Disease

10:53am  |  Cierla McGuire Sams
Rare and potentially pathogenic variants in thehydroxycarboxylic acid receptor genes identified in breast cancer cases

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Douglas Martin, PhD
Director, Scott-Ritchey Research Center
Professor, Department of Anatomy, Physiology and Pharmacology

Douglas R. Martin, PhD, has 25 years’ experience with developing therapies for fatal neurologic disorders such as Tay-Sachs disease, Sandhoff disease and GM1 gangliosidosis. As co-founder of the Tay-Sachs Gene Therapy Consortium, Dr. Martin works closely with a team of scientists, physicians and families dedicated to treating these disorders. He has been inspired by heroic families and patients and by the heroic animals that enable therapy development. Using gene therapy, the survival of affected cats has increased from 8 months (untreated) to an average of 5 years, with some treated animals alive and well at >8 years of age. Such results have supported the initiation of a first-in-human gene therapy clinical trial for GM1 patients at the National Institutes of Health (ClinicalTrials.gov Identifier NCT 03952637) and a similar trial for Tay-Sachs and Sandhoff diseases at the University of Massachusetts Medical School. At the same time, the disease-causing mutations discovered by Dr. Martin and colleagues have been eradicated from cat breeds such as Korat and European Burmese through an international carrier screening program.

Dr. Martin is a native of northeastern Ohio but has lived in Alabama for many years, having completed both his Bachelor of Science (Biology) and PhD (Biomedical Science) degrees at Auburn University. Currently he is a Professor of Anatomy, Physiology & Pharmacology and Director of the Scott-Ritchey Research Center at the Auburn University College of Veterinary Medicine. His research has generated over $11 million in extramural funding and licensing fees from sources such as the National Institutes of Health, the National Tay-Sachs & Allied Diseases Association and biotechnology companies. Among Dr. Martin’s chief accomplishments is helping to train the next generation of researchers. Through his laboratory and as an instructor in the professional veterinary curriculum, Dr. Martin teaches numerous graduate, veterinary and undergraduate students. Along with many pets, he lives in Opelika, Alabama with his lovely wife, who is a veterinarian and private practice owner. He has two beautiful, adult step-daughters who reside in Phoenix and New York City.

View Abstracts

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Undergraduate Students

Madison Hogans
Poster
Towards Elucidation of Canine Adenovirus type 2 tropism

Daniel Patton
Poster
Production of Anti-PD1 antibody by modified Canine Adenovirus-2

Veterinary Students

Tom Bunch
Poster
Awareness and perception of Breed-Specific Legislation in a College of Veterinary Medicine

Grace Duer
Poster
Surgical Correction and Prophylactic Surgical Correction of Third Eyelid Gland Prolapse: A Retrospective Study

Sarah Ezell
Poster
Characterization of the Cannabinoid Receptor – 1 Gene in Three Beagle Dogs and Six Cats

Chloe Haynes
Poster
Engineering a bispecific molecule to simultaneously inhibit and co-stimulate immune checkpoints for combination immunotherapy of canine cancer

Sarah Hoke
Poster
Investigation of Classification Accuracy and Clinical Management Trends of Corneal Ulcer Types Between General Practitioners and Ophthalmologists

Graduate Students

Taylor Abernathy
Poster
Trichloroethylene (TCE) toxicity in zebrafish (Danio rerio): a multigenerational approach

Sophie Boorman
Standing jejunal enterotomy for resolution of an ileal impaction

Wenqi Cao
Poster
Identification of embryonic genomic imprinting pattern using RNA-seq analysis in a marsupial model Monodelphis domestica

Renlei Ji
Poster
Topmouth culter (Culter alburnus) melanocortin-3 receptor: regulation of pharmacology by two isoforms of melanocortin receptor accessory protein 2

Ting Liu
Poster
Regulation of Melanocortin-5 Receptor Pharmacology by Two Isoforms of MRAP2 in Swamp eel (Monopterus albus)

Xiaolei Ma
Poster
Effects of lactocrine insufficiency from birth on the uterine transcriptome and gut microbiome in neonatal pigs on postnatal day 14

Monica Midon
Poster
Invasive blood pressure in anesthetized horses: does the artery site matter?

Monica Midon
Poster
Capnography waveform during Anesthetic Index determination in chickens (Gallus gallus domesticus)

Haolong Wang
Poster
Elucidating the immunomodulatory mechanism of growthpromoting biodegradable microparticles using RNA-seq in mouse macrophages

Xiao Xiong
Poster
Phylogenomic analysis of the intracellular symbiont Wolbachia in arthropods reveals genome evolution and interclade recombination events

Sandra Zetterstrom
Poster
An ex-vivo study of a minimally invasive technique for tenotomy of the tibial insertion of the semitendinosus muscle in horses

Sandra Zetterström
Poster
An ex-vivo Study of Double Hemitenotomy for Lengthening of the Equine Deep Digital Flexor Tendon

Yihang Zhou
Poster
Whole-genome shotgun metagenomic analysis revealed gut microbiome changes in beef cattle under endophyte-infected tall fescue toxicosis

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Graduate Students (continued)

1:30pm  |  Mariano Mora Pereira  |  Presentation
Equine arterial ring assay as an ex vivo model for vasculogenesis in horses

1:42pm  |  Peter Neasham
Developing an in vitro system to identify mechanisms of Influenza A virus (IAV) species adaptation using human and swine respiratory epithelial cells

1:54pm  |  James North
Interspecies Transmission of Influenza A Viruses and the Emergence of Pandemic Viruses

2:06pm  |  Saba Omer
Cannabidiol (CBD) induced inhibition of cancer cell viability in canine B and T-Cell Lymphoma

2:18pm  |  Vasileios Pliasas  |  Presentation
Influenza neuraminidase virus-like particle vaccine platform as a candidate universal influenza vaccine in the porcine model

2:30pm  |  Julia Salamat
Pregnenolone 16-alpha Carbonitrile, an Agonist of Rodent Pregnane X Receptor, can Impair Testosterone Biosynthesis in Rodent Leydig Cells

2:42pm  |  Olivia Stephenson
The prognostic significance of exon 8 c-kit mutations in canine mast cell tumors

2:54pm  |  Huifei Zheng
Thyroid hormone upregulates Dhcr24 expression in adrenal gland

Faculty/Postdoctoral Fellows/Staff

3:06pm  |  Julie Gard Schnuelle  |  Presentation
Treatment of Bovine Tritrichomonas foetus with an Extended Release Topical Formulation

3:18pm  |  Ashley Smith
Evaluation of zoledronate for the treatment of canine metastatic osteosarcoma

3:30pm  |  Alissandra Rha
Genome editing as a potential therapeutic strategy for GM1 gangliosidosis

3:48pm  |  Amanda Gross
Effect of administration route and AAV serotype for treatment of feline GM1 gangliosidosis