The medical and surgical diagnostic tests and treatments of animals are similar to those in human medicine. In order to advance knowledge, researchers and clinicians at the College of Veterinary Medicine perform studies that investigate new diagnostics and treatments. These discoveries can often be applied to medicine across all species.
Most clinical trials are based on preliminary laboratory research data that indicate that the new approach is better than what is already available. Benefits to patients in clinical trials include the potential for life-saving therapy when other treatments have failed, lower-cost treatment or diagnostic options, and the advancement of knowledge that will help future patients. Clinical trials are only performed with informed owner consent. The benefits, risks, and requirements of enrolling in a specific clinical trial is discussed with every client to determine whether participation is the right choice for that patient.
Clinical trials are through one of the Teaching Hospital’s specialty services, typically the Oncology Service, in conjunction with research faculty at the College of Veterinary Medicine.
Canine Immunoneurotherapeutics Trial (CANINE)
The Canine Immunoneurotherapeutics Trial (CANINE) uses human therapies to treat and study canine brain tumors. Dogs and humans develop malignant brain tumors at about the same rate, and these tumors are biologically similar. This trial allows us to provide compassionate care to animals, advance the field of veterinary medicine and better understand the biological effects of treatment. Discovering what we have in common may just lead to a cure.
Other Ongoing Clinical Trials
Cannabidiol (CBD) Pain Treatment in Dogs with Osteoarthritis
Legalization of industrial hemp has led to dietary supplements containing cannabidiol (CBD) for animals. Among the indications of CBD is pain. Osteoarthritis (OA) is one of the most common causes of pain in dogs. The goal of this study is to determine if a CBD containing dietary supplement is an effective and safe treatment for pain associated with OA in dogs. Dogs will be treated for 6 weeks and response to the treatment will be measured prior to, in the middle and at the end of the 6 week period.
- Cannabidiol (CBD) Pain Treatment in Dogs with Osteoarthritis Study Informational Flyer (PDF)
- Consent Form – The safety and efficacy of a dietary supplement containing cannabidiol (CBD) for treatment of pain in dogs with osteoarthritis (PDF)
Comparison of Sentinel Lymph Node Mapping Patterns in Dogs
The goal is to determine if the sentinel lymph node (SLN) is the same or different before and after surgical removal of the mast cell tumors (MCT). If we can retroactively identify the SLN in dogs who have had their MCTs previously removed, then we can identify a larger subset of dogs with metastatic disease. These dogs can therefore be offered additional treatment which may ultimately improve survival times.
- Consent Form – Comparison of sentinel lymph node mapping patterns pre- and post-surgical excision of mast cell tumors using indirect lymphography in client owned dogs (PDF)
Efficacy of Temozolomide for Oral Malignant Melanoma in Dogs
Temozolomide (TMZ) has a documented response rate for the treatment of metastatic melanoma in humans and could represent an oral alternative for systemic treatment of canine melanoma. At this time there has been no investigation of the response rates of canine oral melanoma to TMZ when TMZ is dosed at its most recently published dose in dogs with cancer. The goal of this study is to establish a response rate for TMZ in dogs with oral melanoma at this dose.
Translating research and medicine from one species to another. One Medicine. One Health.
Wilford & Kate Bailey Small Animal Teaching Hospital
1220 Wire Road
College of Veterinary Medicine
Auburn University, AL 36849