Research Interests
My research focuses on the neuroendocrine control of reproduction. Specifically, what factors mediate the release of gonadotropin releasing hormone (GnRH) and the subsequent release of gonadotropins (luteinizing hormone and follicle stimulating hormone) from the anterior pituitary. GnRH regulation requires the translation of neural and hormonal inputs into a precisely regulated output to achieve normal sexual development and gonadal function. Changes in the pulsatile secretion of GnRH are critical for the regulation of events leading to ovulation, inhibition of ovulation prior to puberty and during other physiological periods of infertility. Despite the importance of GnRH neuronal activity in mammalian reproduction, little is known about the inputs controlling the coordination of GnRH neurons resulting in pulsatile and preovulatory release. The paucity of knowledge is due to the fact that GnRH neurons have a limited number of synaptic inputs and express a relatively small number of steroid receptors. One way to identify the underlying mechanisms involved in the normal control of GnRH neurons is to examine the system during periods of distress or after developmental insults. Therefore, my research examines the effects of environmental neuroendocrine disruptors on GnRH activation. In doing so, we will be better able to identify those factors essential for normal reproductive function and develop intervention strategies to protect against environmental factors that may perturb normal reproductive function.
