The Clinical Pharmacology Lab (CPL), under the direction of Dawn Merton Boothe, DVM, PhD, DACVIM (Internal Medicine) DACVCP, provides quality drug analysis services, analytical support and Therapeutic drug monitoring for veterinary practitioners and commercial veterinary diagnostic laboratories in the United States and abroad. Support is also provided for other parties interested in the detection and/or quantitation of drugs or other compounds in a variety of media/body tissues.
The CPL studies the detection, quantification, actions, uses and effects drugs in companion and exotic animals. The CPL also develops new or improves upon previously established analytical procedures for the detection of drugs in blood.
The laboratory has the expertise and commitment to perform validation tests for all assays and perform quality assurance determinations for all studies. The laboratory is equipped with analytical equipment’s including but not limited to the Siemens Dimension Xpand Plus and High Performance Liquid Chromatography had has access to mass spectrometry.
The Pharmacology lab will soon begin offering TDM testing for cannabionid products and plants. Please see the tab below for further information.
Monday – Friday
8:00 a.m. to 5:00 p.m. (CST)
To submit samples for therapeutic drug monitoring (TDM), please use the Sample Submission Form link below.
For research sample submissions, please use the Research Sample Submission Spreadsheet.
If you encounter any problems or need assistance with the submission process, please call us at (334) 844-7187
Ship Samples To:
Clinical Pharmacology Laboratory
1500 Wire Rd.
Auburn University, AL 36849
FedEx Discounted Rate Program
If you use our online submission form, you can take advantage of our FedEx discount and save up to 50% on standard overnight shipping. As soon as your sample information has been submitted, you will see an option to print a FedEx label as well as an estimated cost of shipping via that label.
While FedEx is our preferred method of shipping, UPS Next Day Air Saver can be used if it is more convenient for you.
When serum is requested (see specific test requirements protocol), please draw in red top tube (no serum separator tubes due to binding of drug), allow time to clot, spin down, draw off and send just the serum. This provides the cleanest sample and therefore, the most accurate results.
We are constantly involved in research efforts that strive to advance veterinary medicine. This research includes internal projects, graduate studies, and external sample submissions.
Current Research Projects
Small Animal E. coli Antimicrobial Resistance Survey (SAECARS)
- Project Description: Epidemiological investigation to help delineate risk factors and current patterns of antimicrobial resistance in clinical canine and feline E. coli.
Pharmacokinetic and Pharmacodynamic study of Fosfomycin in Canines.
- Project Description: Measuring plasma drug concentrations after oral and IV administration of Fosfomycin to canines and looking for common side effects or complications.
FRET-based, High-level Fluoroquinolone Resistance in E. coli Assay
- Project Description: Development and validation of a rapid, FRET-based, quantitative PCR Assay to identify High-level Fluoroquinolone Resistance in e. coli isolated from canine urine.
The Clinical Pharmacology Lab offers Analytical Service that can be used for research projects consisting of multiple samples and potential data analysis. This is different from Therapeutic Drug Monitoring on clinical patients.
Our costs generally range from $25-$200 depending on number of samples and ease of detection which is based on several factors (extraction, reagent costs, specificity [e.g. parent compound, metabolites, or enantiomers], sensitivity, previously developed method). For example, an assay that is currently being run in our laboratory is likely to be less expensive than an assay that must be fully developed and validated for a new compound or species.
To request a quote for analytical service, simply complete the Analytical Service Request Form and submit by fax, email, or mail. We will respond with an estimate of price and turn-around time.
The Clinical Pharmacology Lab has already developed the following assays:
|Amikacin||Immunoassay||Canine, Feline||Serum, Plasma, Buffer|
|Bromide (Potassium/Sodium)||Spectrophotometer||Canine, Avian||Serum, Plasma, Buffer, Solutions, Capsules|
|Carvedilol||HPLC||Canine, Feline||Serum, Plasma, Capsules, Buffer|
|Cyclosporine||Immunoassay||Canine, Feline||EDTA Whole Blood|
|Enrofloxacin||HPLC||Canine, Feline, Equine||Serum, Plasma, Buffer|
|Dilantin (Phenytoin)||Immunoassay||Canine||Serum, Plasma|
|Digoxin||Immunoassay||Canine, Equine||Serum, Plasma|
|Keppra (Levetiracetam)||Immunoassay||Canine, Feline||Serum, Plasma|
|Lidocaine||Immunoassay||Canine, Feline||Serum, Plasma|
|Meloxicam||HPLC||Hawk, Owl||Serum, Plasma|
|Methimazole||HPLC||Feline||Serum, Plasma, Buffer, Suspensions|
|Metronidazole||HPCL||Feline||Serum, Plasma, Buffer, Suspensions|
|Metronidazole Benzoate||HPLC||Feline||Serum, Plasma, Buffer, Suspensions|
|Phenobarbital||Immunoassay||Canine, Feline||Serum, Plasma|
|Prednisone||HPLC||Feline||Serum, Plasma, Buffer, Suspensions|
|Prednisolone||HPLC||Feline||Serum, Plasma, Buffer, Suspensions|
|Theophylline||Immunoassay||Canine, Feline||Serum, Plasma|
|Tramadol (and metabolites)||HPLC||Equine||Serum, Plasma|
|Vancomycin||Immunoassay||Canine, Feline||Serum, Plasma|
|Zonisamide||Immunoassay||Canine, Feline||Serum, Plasma|
Do you have a patient receiving a cannabionid product/plant? We are establishing a cannabinoid assay that is intended to be offered for both toxicity and efficacy. We offer monitoring at no charge (there is normally a $150 fee charged). We also recommend sending a portion of the preparation that the patient is receiving ($100 cost saving). Please call or use the online submission form.
We will quantitate THC, CBD, CBG, CBN, and CBC. Samples will be batched and thus will not be run immediately.
Submit 0.5 ml of serum or plasma. We recommend two samples, a peak (two hours post dose) and trough (just prior to the second dose).
Indicate “Other” on the submission form and write in “cannabinoids.” Indicate “efficacy” or “toxicity” (which might include concerns for substance abuse by owner).
Information on the submission form must be complete. This includes, in addition to patient/clinical identification:
- Signalment (species, breed, age, weight)
- Dosing Information:
- Preparation information (be as specific as possible please, including oil, plant, etc)
- Source (ie, company)
- Dose (mg/kg)
- Duration of therapy
- What is being treated
- If the patient has responded
If you are sumbitting for toxicity reasons, provide as much specific information as possible.
As always, specific patient information will be kept confidential.
Results will be sent, when analyzed, as with other TDM.
As a part of the Veterinary Teaching Hospital, the clinical pharmacology laboratory fulfills its commitment to teaching at several levels. Instruction at the professional level begins in the second year during the basic Pharmacology course, and continues throughout the third and fourth years in the form of Clinical Pharmacology electives and clinical case management problems. A Drug Information Center consisting of books, journals, articles and a computer based drug reference library is available for students and faculty. Graduate students in Clinical Pharmacology can work toward degrees at either the MS or PhD levels. A Clinical Pharmacology Residency program has been approved by the ACVCP. In addition to professional and graduate students, many undergraduates have an opportunity to participate in ongoing research.
The CPL is 100% self-supported with the exception of the Director’s salary which is supported by Auburn University. Funds for the CPL are derived from the TDM and analytical services. All funds generated by CPL activities are directly used to support the laboratory and contribute substantially to the research efforts of the laboratory. In addition to self-generated funds, the CPL pursues clinical research funds through grants offered by private and other foundations that support clinical veterinary research.